Genetic influence on type 2 or Clara cell origin of pulmonary adenomas in urethan-treated mice.
Genetic influence on type 2 or Clara cell origin of pulmonary adenomas in urethan-treated mice.
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DOI：
10.1093/jnci/75.5.963
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发表时间：
1985-11
期刊：
影响因子：
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通讯作者：
David G. Beer;Alvin M. Malkinson
中科院分区：
文献类型：
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作者：
David G. Beer;Alvin M. Malkinson
由肺泡2型细胞和细支气管Clara细胞引起的乌拉坦诱导的肺腺瘤具有不同的组织学模式;在单次乌拉坦注射后14-16周，对A/J、SWR/J、BALB/cByJ、129/J和RIIIS/J近交系小鼠中发现的所有肺腺瘤进行检查，证明两种肿瘤类型均存在于所有五种品系中。每种肿瘤类型的相对数量在不同菌株之间差异显着。在形成的肿瘤类型和肿瘤多样性之间没有观察到相关性。在注射乌拉坦后，通过长期丁基化羟基甲苯（BHT）治疗增加肿瘤多样性并没有改变单独使用乌拉坦观察到的2种肿瘤的比例。这一发现表明，BHT对两种肿瘤类型的发展具有同等的刺激作用。新生BALB小鼠单次注射乌拉坦后14周发现的肿瘤大于成年BALB小鼠注射乌拉坦后14周发现的肿瘤，但两组肺泡和乳头状肿瘤的比例相同。淋巴细胞浸润到肿瘤中主要与Clara细胞源性肿瘤相关。2型细胞和Clara细胞来源的肺腺瘤的比例似乎主要由遗传背景控制。
Urethan-induced lung adenomas arising from alveolar type 2 cells and from bronchiolar Clara cells have distinct histologic patterns; and examination of all lung adenomas found in A/J, SWR/J, BALB/cByJ, 129/J, and RIIIS/J inbred mice, 14-16 weeks after a single urethan injection, demonstrated that both tumor types were present in all five strains. The relative numbers of each tumor type varied significantly among the different strains. No correlation was observed between the type of tumor formed and tumor multiplicity. Augmentation of tumor multiplicity by chronic butylated hydroxytoluene (BHT) treatment following urethan injection did not change the proportion of the 2 tumors from that observed with urethan alone. This finding demonstrated that BHT stimulated the development of both tumor types equally. The tumors found 14 weeks after a single urethan injection into neonatal BALB mice were larger than those found 14 weeks after urethan injection into adult BALB mice, but the proportion of alveolar and papillary tumors was the same for both groups. Lymphocytic infiltration into tumors was mainly associated with Clara cell-derived tumors. The proportion of type 2 cell- and Clara cell-derived lung adenomas appeared to be controlled primarily by the genetic background.