Collective cell migration in development.
Collective cell migration in development.
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DOI：
10.1083/jcb.201508047
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发表时间：
2016-01-18
期刊：
影响因子：
--
通讯作者：
Mayor R
中科院分区：
文献类型：
--
作者：
Scarpa E;Mayor R
在胚胎发育过程中，组织的重排会导致细菌层的位置，模式化和组织形态发生。血管发芽以及横向线原始，神经元细胞或头胚层的迁移。
During embryonic development, tissues undergo major rearrangements that lead to germ layer positioning, patterning, and organ morphogenesis. Often these morphogenetic movements are accomplished by the coordinated and cooperative migration of the constituent cells, referred to as collective cell migration. The molecular and biomechanical mechanisms underlying collective migration of developing tissues have been investigated in a variety of models, including border cell migration, tracheal branching, blood vessel sprouting, and the migration of the lateral line primordium, neural crest cells, or head mesendoderm. Here we review recent advances in understanding collective migration in these developmental models, focusing on the interaction between cells and guidance cues presented by the microenvironment and on the role of cell–cell adhesion in mechanical and behavioral coupling of cells within the collective.