Spatial representation in the hippocampal formation: a history
Spatial representation in the hippocampal formation: a history
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DOI：
10.1038/nn.4653
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发表时间：
2017-11-01
影响因子：
25
通讯作者：
McNaughton, Bruce L.
中科院分区：
文献类型：
--
作者：
Moser, Edvard I.;Moser, May-Britt;McNaughton, Bruce L.
自从第一个位置细胞被记录下来，认知地图理论被提出以来，海马结构空间表征的研究已经分阶段发展。早期的研究试图验证位置细胞活动的空间性质，并确定其感觉来源。一个新的时代开始与头部方向细胞的发现和实现的重要性的角度和线性运动集成在生成空间地图。第三个时代开始时，研究人员把注意力转向内嗅皮层，这导致了网格细胞和边界细胞的发现。这篇评论将展示如何整合自我运动线索的想法已经形成了我们的理解，从20世纪70年代到今天的空间表征的大脑内嗅系统。现在有可能研究这些系统的专门细胞类型如何协同工作，空间映射可能成为第一个被详细了解的认知功能之一。
Since the first place cell was recorded and the cognitive-map theory was subsequently formulated, investigation of spatial representation in the hippocampal formation has evolved in stages. Early studies sought to verify the spatial nature of place cell activity and determine its sensory origin. A new epoch started with the discovery of head direction cells and the realization of the importance of angular and linear movement-integration in generating spatial maps. A third epoch began when investigators turned their attention to the entorhinal cortex, which led to the discovery of grid cells and border cells. This review will show how ideas about integration of self-motion cues have shaped our understanding of spatial representation in hippocampal-entorhinal systems from the 1970s until today. It is now possible to investigate how specialized cell types of these systems work together, and spatial mapping may become one of the first cognitive functions to be understood in mechanistic detail.