Exposure to Air Pollution during Pregnancy and Childhood, and White Matter Microstructure in Preadolescents
Exposure to Air Pollution during Pregnancy and Childhood, and White Matter Microstructure in Preadolescents
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DOI：
10.1289/ehp4709
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发表时间：
2020-02-01
影响因子：
10.4
通讯作者：
Guxens, Monica
中科院分区：
文献类型：
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作者：
Lubczynska, Malgorzata J.;Muetzel, Ryan L.;Guxens, Monica
背景技术背景：空气污染与脑结构改变有关，但与白色物质微结构的关系尚不清楚。结论：我们评估了怀孕和儿童暴露于空气污染是否与青春期前的白色物质微结构有关。方法：我们使用了来自R世代研究的2,954名儿童的数据。来自荷兰鹿特丹的基于人口的出生队列（2002-2006年）。17种空气污染物的浓度，包括氮氧化物（NOx），颗粒物（PM）和PM的成分估计在参与者的家中在怀孕期间和儿童使用土地利用回归模型。在儿童9-12岁时获得扩散张量图像，并计算各向异性分数（FA）和平均扩散率（MI）。我们进行了调整社会经济和生活方式特征的线性回归。单一污染物分析后，多污染物分析使用删除/替代/添加（DSA）algorithm.RESULTS：在单一污染物分析，在怀孕或儿童期的几种空气污染物的浓度较高，与显着降低FA或较高的MD（p < 0.05）。在DSA选择的妊娠暴露的多污染物模型中，较高浓度的细颗粒物与显著较低的FA [-0.71（95%CI：-1.26，-0.16）/5 μ g/m（3）细颗粒]和较高浓度的元素硅，MD显著较高[0.06（95% CI：0.01，0.11）/100 ng/m（3）硅]。DSA选择的儿童暴露的多污染物模型表明NOx与FA [-0.14（95%CI：-0.23，-0.04）每20 μ g/m（3）NOx增加]，元素锌和PM的氧化电位与MD [0.03（95% CI：0.01，0.04）每10 ng/m（3）锌增加和0.07（95% CI：0.00，0.44）每1 nmol DTT/min/m（3）氧化电位增加]。相互调整的模型，在怀孕期间和儿童期的显着暴露表明显着的关联硅在怀孕期间，锌在儿童期，MD。讨论：在怀孕期间和儿童期暴露于空气污染物的排气管和非排气管排放量与低FA和高MD在青春期前的白色问题。
BACKGROUND: Air pollution has been related to brain structural alterations, but a relationship with white matter microstructure is unclear.OBJECTIVES: We assessed whether pregnancy and childhood exposures to air pollution are related to white matter microstructure in preadolescents.METHODS: We used data of 2,954 children from the Generation R Study. a population-based birth cohort from Rotterdam, Netherlands (2002-2006). Concentrations of 17 air pollutants including nitrogen oxides (NOx), particulate matter (PM), and components of PM were estimated at participants' homes during pregnancy and childhood using land-use regression models. Diffusion tensor images were obtained at child's 9-12 years of age, and fractional anisotropy (FA) and mean diffusivity (MI)) were computed. We performed linear regressions adjusting for socioeconomic and lifestyle characteristics. Single-pollutant analyses were followed by multipollutant analyses using the Deletion/Substitution/Addition (DSA) algorithm.RESULTS: In the single-pollutant analyses, higher concentrations of several air pollutants during pregnancy or childhood were associated with significantly lower FA or higher MD (p < 0.05). In multipollutant models of pregnancy exposures selected by DSA, higher concentration of fine particles was associated with significantly lower FA [-0.71 (95% CI: -1.26, -0.16) per 5 mu g/m(3) fine particles] and higher concentration of elemental silicon with significantly higher MD [0.06 (95% CI: 0.01, 0.11) per 100 ng/m(3) silicon]. Multipollutant models of childhood exposures selected by DSA indicated significant associations of NOx with FA [-0.14 (95% CI: -0.23, -0.04) per 20-mu g/m(3) NOx increase], and of elemental zinc and the oxidative potential of PM with MD [0.03 (95% CI: 0.01, 0.04) per 10-ng/m(3) zinc increase and 0.07 (95% CI: 0.00, 0.44) per 1-nmol DTT/min/m(3) oxidative potential increase]. Mutually adjusted models of significant exposures during pregnancy and childhood indicated significant associations of silicon during pregnancy, and zinc during childhood, with MD.DISCUSSION: Exposure in pregnancy and childhood to air pollutants from tailpipe and non-tailpipe emissions were associated with lower FA and higher MD in white matter of preadolescents.