Morphometric data on the endothelium of blood capillaries.
Morphometric data on the endothelium of blood capillaries.
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关于血液毛细血管内皮的形态计量数据。
DOI：
10.1083/jcb.60.1.128
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发表时间：
1974-01
期刊：
影响因子：
--
通讯作者：
Palade GE
中科院分区：
文献类型：
--
作者：
Simionescu M;Simionescu N;Palade GE
研究了大鼠肌肉（膈肌、心肌）和内脏（胰腺、空肠绒毛）毛细血管内皮的局部分化。根据每个部分的亚细胞成分和原浆小泡局部频率的变化，在所有这些血管的内皮细胞中可以识别出四个不同的部分：(a)旁连接区，(b)外周区，(c)细胞器区，(d)核区。我们的数据表明，内皮细胞质体积（外周区）的~ 16%、~ 7.0和8.5%分别由囊泡、囊泡内容物和囊泡膜组成。横膈膜的平均囊泡开口密度为78个，心肌为89个，胰腺为25个，空肠粘膜毛细血管为10个。空肠中窗的频率（26个/µm2）是胰腺毛细血管（15个/µm2）的1.7倍，相应的面积分别为内皮表面的~ 9.5%和~ 6%。细胞间隙占内皮细胞内表面相对较小的面积（~ 0.08 ~ 0.2%）。
Local differentiations within the endothelium of both muscular (diaphragm, myocardium) and visceral (pancreas, jejunal villi) capillaries have been studied in rats on sectioned and freeze-cleaved preparations. Four distinct parts have been recognized in the endothelial cells of all these vessels on the basis of subcellular components present in each part and on the basis of variations in the local frequency of plasmalemmal vesicles: (a) the parajunctional zone, (b) the peripheral zone, (c) the organelle region, and (d) the nuclear region. Our data indicate that ∼16, ∼7.0, and 8.5% of the endothelial cytoplasmic volume (in the peripheral zone) is accounted for by vesicles, their content, and their membranes, respectively. The average density of vesicular openings per µm2 is 78 in diaphragm, 89 in myocardium, 25 in pancreas, and 10 in jejunal mucosa capillaries. The frequency of fenestrae is 1.7 times as high in jejunal (26/µm2) as in pancreatic capillaries (15/µm2), the corresponding fractional areas being ∼9.5 and ∼6%, respectively, of the endothelial surface. Intercellular spaces occupy a relatively small area (∼0.08 to 0.2%) of the inner endothelial surface.