Polycythemia and changes in erythropoietin concentration in rats exposed to intermittent hypoxia.
Polycythemia and changes in erythropoietin concentration in rats exposed to intermittent hypoxia.
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DOI：
10.1007/978-1-4419-1241-1_17
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发表时间：
2010
影响因子：
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通讯作者：
M. Ishii;T. Iwamoto;A. Nagai;Gen Sasao;Masayuki Iwasaki;I. Kuwahira
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文献类型：
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作者：
M. Ishii;T. Iwamoto;A. Nagai;Gen Sasao;Masayuki Iwasaki;I. Kuwahira
目前尚不清楚血液血红蛋白浓度（[Hb]）是否随间歇性缺氧（IHx）暴露时间的增加而增加并达到恒定水平。此外，尚不清楚血浆促红细胞生成素浓度（[EPO]）是否也随着暴露时间的增加而增加。使用大鼠模型，首先，我们评估了[EPO]的变化后，每小时单次暴露于10%O2 120分钟，以确定[EPO]的峰值水平。第二，我们评估了10%O2、120 min/d的IHx 0（对照）、1、2、3、4、6和8周对[Hb]、动脉血压（BP）、心率（HR）、动脉血气（ABGs）和[EPO]的影响。[EPO]停止单次低氧暴露后，其含量增加，1h达高峰，18 h内逐渐下降至对照组水平。10%O_2、120 min/d的IHx使[Hb]呈时间依赖性增加，暴露6周后[Hb]达到恒定水平。暴露4周后血压升高，并保持升高。两组心率、动脉血气无显著性差异。[EPO][EPO]峰值在[Hb]达到一定水平后明显下降。
It is not clear whether blood hemoglobin concentration ([Hb]) increases with an increase in the exposure period of intermittent hypoxia (IHx) and reaches a constant level. Furthermore, it is not known whether plasma erythropoietin concentration ([EPO]) also increases with an increase in the exposure period. Using a rat model, first, we evaluated changes in [EPO] every hour after single exposure of 10% O2for 120 min in order to determine a peak level of [EPO]. Second, we evaluated the effect of IHx of 10% O2, 120 min/day for 0 (control), 1, 2, 3, 4, 6 and 8 weeks on [Hb], arterial blood pressure (BP), heart rate (HR), arterial blood gases (ABGs) and [EPO]. [EPO] increased after cessation of the single hypoxic exposure, reached a peak at 1 h, and decreased gradually to the control levels within 18 h. IHx of 10% O2, 120 min/day, produced a time-dependent increase in [Hb], and [Hb] reached a constant level after the exposure for 6 weeks. BP increased after the exposure for 4 weeks and remained elevated. There was no significant difference in HR and ABGs. [EPO] increased significantly and remained elevated at the same level for 1–3 weeks, however, the peak level of [EPO] declined markedly after [Hb] reached a constant level.