LSH hamster model of syphilitic infection
LSH hamster model of syphilitic infection
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LSH仓鼠梅毒感染模型
DOI：
10.1128/iai.28.3.909-913.1980
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发表时间：
1980
影响因子：
3.1
通讯作者：
O. Bagasra
中科院分区：
文献类型：
--
作者：
R. Schell;J. Lefrock;J. Chan;O. Bagasra
近交系LSH/Se LAK仓鼠能感染地方性梅毒病原体--梅毒螺旋体波斯尼亚A。当感染时，该菌株持续产生广泛的慢性皮肤病变，持续6至9个月，即使在抗密螺旋体抗体滴度达到峰值的情况下。淋巴结重量增加，含有可测量数量的密螺旋体。这种感染也使仓鼠对T. pallidum Nichols和Treponema pertenue，分别是性病梅毒和frambesia的病原体。因此，LSH仓鼠是研究梅毒感染的免疫应答机制的极好模型。
The inbred LSH/Se LAK strain of hamster can be infected with Treponema pallidum Bosnia A, the causative agent of endemic syphilis. When infected, this strain consistently produced extensive chronic skin lesions that persisted for 6 to 9 months, even in the presence of peak antitreponemal antibody titers. The lymph nodes increased in weight and contained measurable numbers of treponemes. This infection also gave the hamster cross-immunity to T. pallidum Nichols and Treponema pertenue, the causative agents of venereal syphilis and frambesia, respectively. LSH hamsters are thus an excellent model to study the immune response mechanisms to syphilitic infection.