Ciguatera: A public health perspective
Ciguatera: A public health perspective
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DOI：
10.1016/j.toxicon.2009.09.008
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发表时间：
2010-08-15
期刊：
影响因子：
2.8
通讯作者：
Plakas, Steven M.
中科院分区：
文献类型：
--
作者：
Dickey, Robert W.;Plakas, Steven M.
雪卡毒素鱼中毒是一种由食用积累了脂溶性雪卡毒素的鱼类引起的海鲜传播疾病。在美国，雪卡毒素是导致有鳍鱼类引起的食源性疾病暴发的最高报告发生率的原因，据报告，在全球范围内都是如此。雪卡毒素穿过海洋食物网，从初级生产者，甘比盘属，到世界热带和亚热带地区通常食用的鱼类。雪卡毒素包括加勒比和大西洋热带鱼类中的12种已知同系物和太平洋鱼类中的29种已报告同系物。扩大来自雪卡鱼流行地区的渔业贸易有助于扩大非流行地区海产食品消费者的疾病分布和增加疾病发生频率。雪卡毒素产生一系列复杂的胃肠道、神经系统和心脏病症状。治疗方案非常有限，而且只能起到支持作用。从雪卡毒素爆发的研究中获得的信息提高了临床识别、确认和及时治疗。这些研究对于区分不同区域鱼类中的雪卡毒素分布、确定人体毒性阈值和制定安全限度同样重要。从病例和疫情调查中获得的分析信息被用来得出太平洋和加勒比海地区的雪卡毒素阈值污染率，对海鲜消费者产生不利影响。对这些阈值估计值应用了10倍安全系数，以解决个人风险因素、鱼类消费量的不确定性和分析准确性。这些研究可作为行业和消费者咨询水平的基础，即热带大西洋、墨西哥湾、加勒比海鱼类中的0.10 ppb C-CTX-1当量毒性和太平洋区域鱼类中的0.01 ppb P-CTX-1当量毒性。爱思唯尔有限公司出版
Ciguatera fish poisoning is a seafood-borne illness caused by consumption of fish that have accumulated lipid-soluble ciguatoxins. In the United States, ciguatera is responsible for the highest reported incidence of food-borne illness outbreaks attributed to finfish, and it is reported to hold this distinction globally. Ciguatoxins traverse the marine food web from primary producers, Gambierdiscus spp., to commonly consumed fish in tropical and subtropical regions of the world. Ciguatoxins comprise 12 known congeners among Caribbean and tropical Atlantic fish and 29 reported congeners among Pacific fish. Expanding trade in fisheries from ciguatera-endemic regions contributes to wider distribution and increasing frequency of disease among seafood consumers in non-endemic regions. Ciguatoxins produce a complex array of gastrointestinal, neurological and cardiological symptoms. Treatment options are very limited and supportive in nature. Information derived from the study of ciguatera outbreaks has improved clinical recognition, confirmation, and timely treatment. Such studies are equally important for the differentiation of ciguatoxin profiles in fish from one region to the next, the determination of toxicity thresholds in humans, and the formulation of safety limits. Analytical information from case and outbreak investigations was used to derive Pacific and Caribbean ciguatoxin threshold contamination rates for adverse effects in seafood consumers. To these threshold estimates 10-fold safety factors were applied to address individual human risk factors; uncertainty in the amount of fish consumed; and analytical accuracy. The studies may serve as the basis for industry and consumer advisory levels of 0.10 ppb C-CTX-1 equivalent toxicity in fish from the tropical Atlantic, Gulf of Mexico, Caribbean, and 0.01 ppb P-CTX-1 equivalent toxicity in fish from Pacific regions. Published by Elsevier Ltd.