Mitochondria and the culture of the Borg: understanding the integration of mitochondrial function within the reticulum, the cell, and the organism.
Mitochondria and the culture of the Borg: understanding the integration of mitochondrial function within the reticulum, the cell, and the organism.
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DOI：
10.1002/bies.201000073
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发表时间：
2010-11
期刊：
影响因子：
4
通讯作者：
McBride, Heidi M.
中科院分区：
文献类型：
--
作者：
Braschi, Emelie;McBride, Heidi M.
作为内共生体，线粒体在细胞器中是独一无二的。这篇综述提供了对线粒体行为的见解，并引入了一个统一集体的概念，一个互联的网状结构，让人想起《星际迷航》电视连续剧中虚构的人形物种博格人，在他们的网络(或“蜂巢”)内做出决定，与协调线粒体和细胞过程之间的串扰的信号级联(“亚空间域”)联系在一起。同样，线粒体的动力学由两个不同的过程决定，即对分裂/融合的局部调控和通过细胞信号通路对其行为的全局控制。事实上，蜂巢内的决定为每个线粒体单位提供了对自身降解的自主控制，从而使线粒体融合失活，成为自噬的底物。亚空间域中的决定将参与线粒体功能整合的信号通路与复杂的细胞转变结合在一起，包括发育线索、有丝分裂和细胞凋亡。
As endosymbionts, the mitochondria are unique among organelles. This review provides insights into mitochondrial behavior and introduces the idea of a unified collective, an interconnected reticulum reminiscent of the Borg, a fictional humanoid species from the Star Trek television series whereby decisions are made within their network (or “hive”), linked to signaling cascades that coordinate the cross-talk between mitochondrial and cellular processes (“subspace domain”). Similarly, mitochondrial dynamics are determined by two distinct processes, namely the local regulation of fission/fusion and the global control of their behavior through cellular signaling pathways. Indeed, decisions within the hive provide each mitochondrial unit with autonomous control of their own degradation, whereby mitochondrial fusion is inactivated and they become substrates for autophagy. Decisions within the subspace domain couple signaling pathways involved in the functional integration of mitochondria with complex cellular transitions, including developmental cues, mitosis, and apoptosis.
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影响因子：
3.5
作者：
Chen H;Chan DC
通讯作者：
Chan DC
影响因子：
64.5
作者：
Chen H;Vermulst M;Wang YE;Chomyn A;Prolla TA;McCaffery JM;Chan DC
通讯作者：
Chan DC
影响因子：
64.8
作者：
Cunningham, John T.;Rodgers, Joseph T.;Puigserver, Pere
通讯作者：
Puigserver, Pere
DOI：
10.1084/jem.20081297
发表时间：
2008-09-29
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chen C;Liu Y;Liu R;Ikenoue T;Guan KL;Liu Y;Zheng P
通讯作者：
Zheng P
DOI：
10.1083/jcb.200211046
发表时间：
2003-01-20
期刊：
The Journal of cell biology
影响因子：
--
作者：
Chen H;Detmer SA;Ewald AJ;Griffin EE;Fraser SE;Chan DC
通讯作者：
Chan DC