Association of Fc gamma-receptor genes polymorphisms with chronic periodontitis and Peri-Implantitis
Association of Fc gamma-receptor genes polymorphisms with chronic periodontitis and Peri-Implantitis
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DOI：
10.1002/jcb.28486
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发表时间：
2019-07-01
影响因子：
4
通讯作者：
Kadkhodazadeh, Mahdi
中科院分区：
文献类型：
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作者：
Saremi, Leila;Esmaeilzadeh, Emran;Kadkhodazadeh, Mahdi
本研究对牙周科的 87 名慢性牙周炎 (CP) 患者、50 名种植体周围炎患者和 90 名牙周健康个体进行了研究，以评估 Fc γ 受体基因多态性与 CP 和种植体周围炎之间的关联。征得患者同意后，采集患者静脉血样本（5cc），并使用米勒盐析法提取DNA。采用聚合酶链式反应(PCR)-限制性片段长度多态性和四引物扩增耐药突变系统-PCR方法评估FcR IIa、IIIa和IIIb基因的多态性。分析显示，在共显性和显性模型中，特定基因型与 CP 和种植体周围炎风险增加之间存在显着相关性。对于 FcR IIIa，分析揭示了在共显性、显性和隐性模型中，特定基因型与 CP 增加和种植体周围炎风险之间存在显着关联。对于 FcR IIIb，我们还在共显性、显性和隐性模型中检测到 CP 增加的特定基因型与种植体周围炎风险之间存在显着关联（P
This study was conducted on 87 patients with chronic periodontitis (CP), 50 patients with peri-implantitis and 90 periodontally healthy individuals referring to the Department of Periodontics for evaluating the association between Fc gamma-receptor genes polymorphisms with CP and peri-implantitis. After obtaining consent, venous blood samples (5cc) were obtained from patients and DNA was extracted using Miller's salting-out method. Polymerase chain reaction (PCR)-restriction fragment length polymorphism and tetra-primer amplification refractory mutation system-PCR methods were used to assess the polymorphisms of FcRs IIa, IIIa, and IIIb genes. Analyzing showed a significant association between specific genotypes with increasing CP and peri-implantitis risks in codominant and dominant models. For FcR IIIa, analyzing revealed a significant association between specific genotypes with increasing CP and peri-implantitis risks in codominant, dominant, and recessive models. For FcR IIIb, we also detected a significant association between specific genotypes with increasing CP and peri-implantitis risks in codominant, dominant, and recessive models (P