Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography.
Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography.
复制标题
使用 X 射线相差显微 CT 在线全息术对软组织小型无血管肿瘤进行成像。
DOI：
10.1117/12.772761
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Krol,Andrzej
中科院分区：
文献类型：
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作者：
Nesterets,Yakov;Gureyev,Tim;Stevenson,Andrew;Pogany,Andrew;Wilkins,Steve;Kincaid,Russell;Ye,Hongwei;Vogelsang,Levon;Lipson,Edward;Coman,Ioana;Fourmaux,Sylvain;Kieffer,Jean-Claude;Krol,Andrzej
为了评估X射线相位衬度同轴全息术用于小软组织无血管肿瘤显微CT成像的可行性，我们研究了具有静止细胞核（< 250 μm）和形成外壳的各种增殖细胞密度（PCD）分布的小球状无血管肿瘤模型的同轴几何结构的显微CT成像。我们已经模拟成像与超快激光为基础的X射线源与钼靶。我们观察到相衬增强的肿瘤边界的重建的横轴图像，从而提高检测小的软组织肿瘤，提供的PCD密度梯度是足够大的。
To assess the feasibility of small soft tissue avascular tumor micro-CT imaging with x-ray phase-contrast in-line holography, we have studied micro-CT imaging with in-line geometry of small spheroidal avascular tumor models with quiescent cell core (< 250 μm) and various distributions of the proliferating cell density (PCD) forming the outer shell. We have simulated imaging with an ultrafast laser-based x-ray source with a Mo target. We observe phase-contrast enhancement of the tumor boundaries in the reconstructed transaxial images, resulting in improved detection of small soft tissue tumors, providing that the PCD density gradient is sufficiently large.