Immunocytokines: a novel class of products for the treatment of chronic inflammation and autoimmune conditions.
Immunocytokines: a novel class of products for the treatment of chronic inflammation and autoimmune conditions.
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DOI：
10.1016/j.drudis.2015.10.012
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发表时间：
2016-01
影响因子：
7.4
通讯作者：
Neri, Dario
中科院分区：
文献类型：
--
作者：
Bootz, Franziska;Neri, Dario
抗体-细胞因子融合蛋白，通常称为免疫细胞因子，代表了一类新型生物制药制剂，它将某些抗体的疾病归巢活性与细胞因子有效负载的免疫调节特性相结合。最初，免疫细胞因子主要是为癌症治疗应用而开发的。然而，最近，已经考虑使用抗炎细胞因子来治疗慢性炎症病症和治疗自身免疫性疾病。本综述分析了免疫细胞因子设计的基本原理，并描述了临床前和临床开发中最先进的产品。
Antibody–cytokine fusion proteins, often referred to as immunocytokines, represent a novel class of biopharmaceutical agents that combine the disease-homing activity of certain antibodies with the immunomodulatory properties of cytokine payloads. Originally, immunocytokines were mainly developed for cancer therapy applications. More recently, however, the use of anti-inflammatory cytokines for the treatment of chronic inflammatory conditions and to treat autoimmune diseases has been considered. This review analyzes basic principles in the design of immunocytokines and describes the most advanced products in preclinical and clinical development.
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