Palladium-catalyzed intramolecular C−H bond functionalization of trifluoroacetimidoyl chloride derivatives: Synthesis of 6-trifluoromethyl-phenanthridines
Palladium-catalyzed intramolecular C−H bond functionalization of trifluoroacetimidoyl chloride derivatives: Synthesis of 6-trifluoromethyl-phenanthridines
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DOI：
10.1016/j.jfluchem.2014.04.005
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发表时间：
2014-07
影响因子：
1.9
通讯作者：
Mei Zhu;W. Fu;G. Zou;Chen Xu;Zhiqiang Wang
中科院分区：
文献类型：
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作者：
Mei Zhu;W. Fu;G. Zou;Chen Xu;Zhiqiang Wang
通过钯催化的三氟乙酰亚胺酰氯的分子内C-H键功能化反应，实现了高效合成6-三氟甲基菲啶衍生物的方法。该反应允许通过C-H键官能化直接形成CSp 2-CSp 2键，并以中到高产率快速获得菲啶环系统，具有良好的官能团耐受性。
Highly efficient approaches to obtain 6-trifluoromethyl-phenanthridine derivatives have been realized through the palladium-catalyzed intramolecular C–H bond functionalization of trifluoroacetimidoyl chlorides. The reaction allows the direct formation of CSp2–CSp2bondsviaC–H bond functionalization and rapid access to phenanthridine ring systems in moderate to high yields with good functional group tolerance.