PLASMODIUM-KNOWLESI IN THE MARMOSET (CALLITHRIX-JACCHUS)
PLASMODIUM-KNOWLESI IN THE MARMOSET (CALLITHRIX-JACCHUS)
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DOI：
10.1017/s0031182000048599
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发表时间：
1979-01-01
期刊：
影响因子：
2.4
通讯作者：
COHEN, S
中科院分区：
文献类型：
--
作者：
LANGHORNE, J;COHEN, S
普通狨猴容易感染诺氏疟原虫疟疾。该寄生虫的形态与在自然宿主（食蟹猴）和常见实验室模型（猕猴）中观察到的形态没有区别。在所研究的 8 只狨猴中观察到对诺氏疟原虫的易感性存在差异。寄生虫的繁殖率在 24 小时内变化。攻击后 12-17 天内，五只动物死于暴发性感染。三只动物从感染中自然恢复，随后对诺氏疟原虫的同源和异源变体和菌株的攻击具有抵抗力。这种抵抗力在攻击感染之间可以维持长达 100 天的时间间隔。
Common marmosets were susceptible to P. knowlesi malaria. The morphology of the parasite was indistinguishable from that observed in the natural host (Macaca fascicularis) and the common laboratory model (Macaca mulatta). A differential susceptibility to P. knowlesi was observed in the 8 marmosets studied. Multiplication rates of parasites were variable over 24 h periods. Five animals died of a fulminating infection within 12-17 days after challenge. Three animals recovered spontaneously from infection and were subsequently resistant to challenge with homologous and heterologous variants and strains of P. knowlesi. This resistance was maintained for intervals up to 100 days between challenge infections.