STRUCTURAL-CHANGES IN ENDOTHELIAL-CELLS OF DEVELOPING RAT-LIVER IN THE TRANSITION FROM FETAL TO POSTNATAL LIFE
STRUCTURAL-CHANGES IN ENDOTHELIAL-CELLS OF DEVELOPING RAT-LIVER IN THE TRANSITION FROM FETAL TO POSTNATAL LIFE
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DOI：
10.1016/s0889-1605(86)80018-0
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发表时间：
1986-10-01
期刊：
影响因子：
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通讯作者：
VIDALVANACLOCHA, F
中科院分区：
文献类型：
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作者：
BARBERAGUILLEM, E;ARRUE, JM;VIDALVANACLOCHA, F
本文用扫描电镜图象分析法研究了胎鼠（18和21天）、新生鼠（1和5天）和成年鼠肝微循环壁的内皮窗。我们的研究结果表明，肝内皮细胞包含不同的开窗模式，这取决于它们在肝腺泡中的特定位置和发育时期。与成人肝脏一样，胎儿和出生后肝脏的门静脉血管具有连续的内皮。中央静脉的内皮细胞从胎儿和新生儿肝脏的高度有孔到成人肝脏的连续。沿着胎儿肝脏的窦状隙网络，每平方微米内皮细胞的窗孔数是沿着相似的，但是在新生儿肝脏的3区窦状隙中通过成人肝脏增加，其中在1区窦状隙中增加了三倍。在胎儿到出生后的过渡期，由于伴随残余造血活性的大窗孔（>250 nm）消失，窦内皮的孔隙度值逐渐降低。虽然我们不知道哪些因素具体调节这些开窗模式，但在肝组织在出生后承担其异质性功能之前，它们在胎肝中的构型值得注意。
Endothelial fenestrae in the microciruclatory walls of fetal (18th and 21st days), newborn (1st and 5th days) and adult rat livers have been studied by an interction analysis of scanning electron microscope images. Our results show that liver endothelial cells contain different fenestration patterns depending on both their specific location in the liver acinus and the developing period. Portal vessels have a continuous endothelium in both fetal and postnatal livers as in the adult liver. Endothelial cells in central veins change from highly fenestrated in the fetal and neonatal livers to continuous in the adult liver. The number of fenestrae per square micrometer of endothelium is similar along the sinusoidal network of fetal liver, but increases in the zone 3 sinusoids of newborn liver through the adult liver, where it has tripled the number in the zone 1 sinusoids. Porosity values in sinusoidal endothelium progressively decrease in the fetal to postnatal transition due to the disappearance of large fenestrae (>250 nm) which accompanies the residual hemopoietic activity. While we do not know which factors specifically regulate thse fenestration patterns, their configuration in fetal liver, before hepatic tissue has assumed its hetereogeneous functioning postnatally, is worthy of note.