Highly efficient separation of strongly hydrophilic structurally related compounds by hydrophobic ionic solutions
Highly efficient separation of strongly hydrophilic structurally related compounds by hydrophobic ionic solutions
复制标题
通过疏水性离子溶液高效分离强亲水性结构相关化合物
DOI：
10.1002/aic.16013
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发表时间：
2018-04
期刊：
影响因子：
3.7
通讯作者：
Ren Qilong
中科院分区：
文献类型：
--
作者：
Yang Qiwei;Guo Shaocong;Liu Xianxian;Zhang Zhiguo;Bao Zongbi;Xing Huabin;Ren Qilong
由于分离选择性和容量之间的权衡，选择性分离水溶液中强亲水性结构相关化合物是一个长期存在的挑战。本研究以L-抗坏血酸2-葡萄糖苷（AA-2G）和L-抗坏血酸为模型化合物，通过疏水性离子溶液的液液萃取分离强亲水性结构相关化合物。在不使用强酸和强碱的条件下，溴化磷离子液体和非质子分子稀释剂用量少，萃取容量大，分配系数高，分子选择性好，循环性能好。这种方法的本质是强氢键碱性和良好疏水性的成功结合，沿着构建的离子溶液的显著优先溶剂化现象。即使在100 mg/mL的高进料浓度下，AA-2G的纯度也可以从50%大大提高到96.2%，经过五级逆流萃取后，收率几乎为100%。© 2017美国化学工程师学会AIChE J，64：1373-1382，2018
The selective separation of strongly hydrophilic structurally related compounds in aqueous solutions is a long‐standing challenge due to a trade‐off between separation selectivity and capacity. This work shows a new method to separate strongly hydrophilic structurally related compounds through hydrophobic ionic solution‐based liquid‐liquid extraction, with L‐ascorbic acid 2‐glucoside (AA‐2G) and L‐ascorbic acid as model compounds. Extraordinary distribution coefficient, superb molecular selectivity, large extraction capacity and good recyclability without using strong acids and salts were all achieved, with a small consumption of phosphonium bromide ionic liquid and aprotic molecular diluent. The essence of this method is the successful combination of both strong hydrogen‐bond basicity and good hydrophobicity along with significant preferential solvation phenomena of the constructed ionic solutions. Even if at a high feed concentration of 100 mg/mL, the purity of AA‐2G could be greatly elevated from 50% to 96.2% with an ultrahigh yield of almost 100% after five‐stage countercurrent extraction. © 2017 American Institute of Chemical EngineersAIChE J, 64: 1373–1382, 2018
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影响因子：
4.2
作者：
Qiwei Yang;Huabin Xing;Yifeng Cao;Bao-gen Su;Yiwen Yang;Qilong Ren
通讯作者：
Qiwei Yang;Huabin Xing;Yifeng Cao;Bao-gen Su;Yiwen Yang;Qilong Ren
影响因子：
15
作者：
KAMLET, MJ;TAFT, RW
通讯作者：
TAFT, RW
影响因子：
3.7
作者：
A. Arce;A. Marchiaro;O. Rodríguez;A. Soto
通讯作者：
A. Arce;A. Marchiaro;O. Rodríguez;A. Soto
影响因子：
2.6
作者：
Neves, Catarina M. S. S.;Carvalho, Pedro J.;Coutinho, Joao A. P.
通讯作者：
Coutinho, Joao A. P.
DOI：
10.1039/p29960002177
发表时间：
1996-10-01
期刊：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2
影响因子：
--
作者：
Bosch, E;Rived, F;Roses, M
通讯作者：
Roses, M