Resting state alpha frequency is associated with menstrual cycle phase, estradiol and use of oral contraceptives
Resting state alpha frequency is associated with menstrual cycle phase, estradiol and use of oral contraceptives
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DOI：
10.1016/j.brainres.2014.06.034
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发表时间：
2014-08-19
期刊：
影响因子：
2.9
通讯作者：
Kerschbaum, Hubert H.
中科院分区：
文献类型：
--
作者：
Broetzner, Christina P.;Klimesch, Wolfgang;Kerschbaum, Hubert H.
休息时持续的内在大脑活动，但清醒的人类由α振荡主导。在人类中，个体α频率（IAF）与认知性能相关。值得注意的是，女性在认知和情感任务中的表现分别与月经周期和性激素水平有关。在本研究中，我们将休息女性的α振荡频率与月经周期阶段、性激素水平或口服避孕药的使用相关。记录了57名自然月经周期妇女（年龄24.07 ± 3.67岁）和57名使用口服避孕药的妇女（年龄22.37 ± 2.20岁）在闭眼坐在扶手椅上时的脑电图（EEG）。α频率与月经周期阶段有关。黄体期女性的TAP或中心频率最高，卵泡晚期女性的TAP或中心频率最低。此外，TAP以及中心频率与内源性雌二醇水平呈负相关，但没有发现与内源性孕酮。使用口服避孕药的女性显示出与卵泡早期女性相似的α频率。我们认为内源性雌二醇调节静息α频率。(C)2014作者由Elsevier B. V.发布。这是CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/3.0/）。
Ongoing intrinsic brain activity in resting, but awake humans is dominated by alpha oscillations. In human, individual alpha frequency (IAF) is associated with cognitive performance. Noticeable, performance in cognitive and emotional tasks in women is associated with menstrual cycle phase and sex hormone levels, respectively. In the present study, we correlated frequency of alpha oscillation in resting women with menstrual cycle phase, sex hormone level, or use of oral contraceptives. Electroencephalogram (EEG) was recorded from 57 women (aged 24.07 +/- 3.67 years) having a natural menstrual cycle as well as from 57 women (aged 22.37 +/- 2.20 years) using oral contraceptives while they sat in an armchair with eyes closed. Alpha frequency was related to the menstrual cycle phase. Luteal women showed highest and late follicular women showed lowest TAP or center frequency. Furthermore, TAP as well as center frequency correlated negatively with endogenous estradiol level, but did not reveal an association with endogenous progesterone. Women using oral contraceptives showed an alpha frequency similar to women in the early follicular phase. We suggest that endogenous estradiol modulate resting alpha frequency. (C) 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).