Anti-epiligrin cicatricial pemphigoid and relative risk for cancer
Anti-epiligrin cicatricial pemphigoid and relative risk for cancer
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DOI：
10.1016/s0140-6736(00)04971-0
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发表时间：
2001-06-09
期刊：
影响因子：
168.9
通讯作者：
Yancey, KB
中科院分区：
文献类型：
--
作者：
Egan, CA;Lazarova, Z;Yancey, KB
目前尚不清楚抗癫痫蛋白瘢痕性类天疱疮（AECP）患者是否有恶性肿瘤的风险增加。我们根据美国国家癌症研究所监测、流行病学和最终结果（NCI SEER）登记处中所有癌症的相应发病率，计算了35例此类患者队列中的预期癌症数量。该队列中有10名患者患有孤立性实体癌; 8名患者在AECP发作后发生癌症（14个月内有7名）。该队列中癌症的相对风险（RR）为6.8（95%置信区间[CI]：3.3-12.5）。AECP似乎与癌症的相对风险增加有关。
It is not known whether patients with anti-epiligrin cicatricial pemphigoid (AECP) have an increased risk of malignancy. We calculated the expected numbers of cancers in a cohort of 35 such patients based on respective incidence rates for all cancers In the National Cancer Institute's Surveillance, Epidemiology, and End Results (NCI SEER) Registry. Ten patients in this cohort had solitary solid cancers; eight patients developed cancer after onset of AECP (seven within 14 months). The relative risk (RR) for cancer in this cohort was 6.8 (95% confidence intervals [CI]: 3.3-12.5). AECP seems to be associated with an increased relative risk for cancer.