Purkinje cell death: Differences between developmental cell death and neurodegenerative death in mutant mice
Purkinje cell death: Differences between developmental cell death and neurodegenerative death in mutant mice
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DOI：
10.1080/14734220600699373
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发表时间：
2006-06-01
期刊：
影响因子：
3.5
通讯作者：
Sotelo, Constantino
中科院分区：
文献类型：
--
作者：
Dusart, Isabelle;Guenet, Jean Louis;Sotelo, Constantino
这篇综述致力于小鼠发育过程中发生的浦肯野细胞死亡和小鼠小脑自发突变。我们首先提出了支持发育性浦肯野细胞死亡的证据。然后，描述和讨论了在突变小鼠中发生的主要影响神经元群体的不同类型的浦肯野细胞变性(神经性、浦肯野细胞变性、Lurcher、Toppler和眩晕)。此外，我们通过报道新的数据表明，转基因突变小鼠的细胞死亡可能与自噬有关。最后，我们讨论了这样一个事实，即突变小鼠的细胞死亡途径比通常所描述的三种发育死亡类型(凋亡、自噬、坏死)更为复杂，因为它们通常具有不止一种发育细胞死亡的特征，特别是自噬和凋亡。
This review is devoted to Purkinje cell death occurring during development and in spontaneous cerebellar mutations of the mouse. We first present evidence in favor of an apoptotic developmental Purkinje cell death. Then, the different types of Purkinje cell degeneration occurring in mutant mice primarily affecting this neuronal population ( nervous, purkinje cell degeneration, Lurcher, toppler, and woozy) are described and discussed. In addition, we show, by reporting new data, that cell death in tambaleante mutant mice can be related to autophagy. Last, we discuss the fact that the cell death pathways in mutant mice are more complex than the three types of developmental death generally described ( apoptosis, autophagy, necrosis), since they share often characteristics of more than one type of these developmental cell deaths, particularly autophagy and apoptosis.