Immunologic defense mechanisms of the ocular surface.
Immunologic defense mechanisms of the ocular surface.
复制标题
眼表的免疫防御机制。
DOI：
10.1016/s0161-6420(83)34510-3
复制
发表时间：
1983
期刊：
影响因子：
13.7
通讯作者：
Gillette,TE
中科院分区：
文献类型：
--
作者：
Chandler,JW;Gillette,TE
眼表面代表了一个免疫微观世界，其中某些与其他粘膜表面相似或相同的局部免疫和副免疫防御系统起作用。这些防御包括常驻正常植物群;内在解剖屏障;粘液和某些化学抑菌剂和溶菌剂的分泌;局部体液（sIgA）抗体分泌;和局部T淋巴细胞细胞应答。一系列复杂的机制已经发展到保护眼表面免受各种环境病原体的侵害。通常，一个系统的激活会导致另一个系统的激活，为宿主防御提供了一系列高度整合的机制。而且，很明显，这些不同机制的紧密整合为宿主防御提供了高效的扩增系统，因此当一种机制无法应对入侵病原体时，下一种机制就会有效启动。只有在病原体破坏这些防御系统的情况下，或者病原体具有持久的性质，以至于它对这些不同机制的去除产生抵抗力，或者能够破坏其身份，从而逃避这些机制，生物体才会感染并引起疾病。毫无疑问，所有这些防御系统（包括副免疫系统和免疫系统）的复杂相互作用最终决定了眼表的完整性。
The ocular surface represents an immunologic microcosm in which certain local immunologic and paraimmunologic defense systems analogous or identical to those of other mucosal surfaces are operative. These defenses include a resident normal flora; intrinsic anatomic barriers; secretion of mucous and certain chemical bacteriostatics and bacteriolytics; local humoral (slgA) antibody secretion; and local T-lymphocyte cellular responses. A series of sophisticated mechanisms has evolved to defend the ocular surface against diverse environmental pathogens. Often, the activation of one system leads to the subsequent activation of another, providing a highly integrated, series of mechanisms for host defense. And, it is clear that close integration of these various mechanisms provides a highly efficient amplification system for host defense, so that when one mechanism fails to deal with the invading pathogen the next mechanism is then efficiently initiated. Only in those situations where the pathogen overwhelms these defense systems, or is of such a persistent nature that it becomes resistant to removal by these various mechanisms, or alternatively is able to subvert its identity and, therefore, evade these mechanisms do organisms infect and cause disease. It is undoubtedly the complex interaction of all of these defense systems, both paraimmunologic and immunologic, which finally determines the integrity of the ocular surface.