DIADENOSINE PHOSPHATES AND THE PHYSIOLOGICAL CONTROL OF BLOOD-PRESSURE
DIADENOSINE PHOSPHATES AND THE PHYSIOLOGICAL CONTROL OF BLOOD-PRESSURE
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DOI：
10.1038/367186a0
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发表时间：
1994-01-13
期刊：
影响因子：
64.8
通讯作者：
ZIDEK, W
中科院分区：
文献类型：
--
作者：
SCHLUTER, H;OFFERS, E;ZIDEK, W
自从发现心钠素1、内皮源性舒张因子2和内皮素3等血管活性物质以来，我们对血管紧张度调节的认识得到了扩展。在血小板中发现了不明血管加压剂4。在这里，我们分离这些血管加压素，并确定他们为五磷酸二腺苷（AP 5A）和六磷酸二腺苷（AP 6A）通过色谱，质谱，紫外光谱和酶裂解。在离体灌注大鼠肾脏的血管系统中，两种磷酸二腺苷在浓度为10（-9）M时均具有活性;在主动脉环中，在10（-8）M时引起收缩。大鼠主动脉内注射导致血压长期升高。我们的结论是，AP 5A和AP 6A可能发挥局部血管调节的一部分，并可能在血压的调节。
OUR understanding of the regulation of vascular tone has been extended since the identification of vasoactive agents such as the atrial natriuretic peptides1, endothelial-derived relaxing factor2 and endothelin3. Unidentified vasopressive agents have been found in platelets4. Here we isolate these vasopressors and identify them as diadenosine pentaphosphate (AP5A) and diadenosine hexaphosphate (AP6A) by chromatography, mass spectrometry, ultraviolet spectroscopy and enzymatic cleavage. In the vasculature of isolated perfused rat kidney, both diadenosine phosphates were active at a concentration of 10(-9) M; in aortic rings, contractions were elicited at 10(-8) M. Intra-aortic injection in the rat caused a prolonged increase in blood pressure. We conclude that AP5A and AP6A may play a part in local vasoregulation and possibly in the regulation of blood pressure.