Gamma electron vertex imaging and application to beam range verification in proton therapy
Gamma electron vertex imaging and application to beam range verification in proton therapy
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DOI：
10.1118/1.3662890
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发表时间：
2012-02-01
期刊：
影响因子：
3.8
通讯作者：
Lee, Han Rim
中科院分区：
文献类型：
--
作者：
Kim, Chan Hyeong;Park, Jin Hyung;Lee, Han Rim
目的：本文描述了一种新的伽马射线成像方法，“伽马电子顶点成像（GEVI）”，可用于质子治疗中精确的射束范围验证。方法：在 GEVI 成像中，来自源或核相互作用的高能伽马首先通过康普顿散射转换为电子，随后由视镜追踪以确定伽马源的位置 或核相互作用的顶点。使用配备 QGSP_BIC_HP 物理包的 GEANT4 通过蒙特卡罗模拟评估了用于束内范围验证的 GEVI 成像的性能。结果：我们的模拟结果表明，即使没有任何复杂的分析，GEVI 成像也可以非常准确地确定质子束范围，误差在 2-3 毫米之内。结果是在单能笔形射束停止在均匀体模中的简化条件下获得的，根据所获得的结果，质子束射程测量有望实现亚毫米精度。结论：如果未来的实验工作证实了本文提出的模拟结果，那么 GEVI 成像的使用预计将在提高患者质子束射程验证的准确性方面具有巨大潜力，从而产生显着的效果。 通过使放射剂量与肿瘤体积紧密一致来提高治疗效果和患者安全。 (C) 2012 年美国医学物理学家协会。 [DOI：10.1118/1.3662890]
Purpose: This paper describes a new gamma-ray imaging method, "gamma electron vertex imaging (GEVI)," which can be used for precise beam range verification in proton therapy.Methods: In GEVI imaging, the high-energy gammas from a source or nuclear interactions are first converted, by Compton scattering, to electrons, which subsequently are traced by hodoscopes to determine the location of the gamma source or the vertices of the nuclear interactions. The performance of GEVI imaging for use in-beam range verification was evaluated by Monte Carlo simulations employing GEANT4 equipped with the QGSP_BIC_HP physics package.Results: Our simulation results show that GEVI imaging can determine the proton beam range very accurately, within 2-3 mm of error, even without any sophisticated analysis. The results were obtained under simplified conditions of monoenergetic pencil beams stopped in a homogeneous phantom and on the basis of the obtained results it is expected to achieve submillimeter accuracy in proton beam range measurement.Conclusions: If future experimental work confirms the simulated results presented in this paper, the use of GEVI imaging is expected to have a great potential in increasing the accuracy of proton beam range verification in a patient, resulting in significant improvement of treatment effectiveness by enabling tight conformation of radiation dose to the tumor volume and patient safety. (C) 2012 American Association of Physicists in Medicine. [DOI: 10.1118/1.3662890]