Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival
Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival
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DOI：
10.1182/blood-2005-11-4334
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发表时间：
2006-06-15
期刊：
影响因子：
20.3
通讯作者：
Shachar, Idit
中科院分区：
文献类型：
--
作者：
Starlets, Diana;Gore, Yael;Shachar, Idit
CD 74是一种整合的膜蛋白，被认为主要作为MHC 11类分子伴侣发挥作用。然而，CD 74最近被证明具有作为辅助信号分子的作用。我们的研究表明，CD 74通过诱导导致NF-κ B p65/RelA同源二聚体及其共激活因子TAF（竖条竖条）介导的转录激活的途径来调节B细胞分化105。在这里，我们表明，CD 74刺激与抗CD 74抗体导致诱导的信号级联反应，导致NF-κ B B活化，进入刺激的细胞进入S期，DNA合成，细胞分裂，并增加BCL-XL的表达。因此，这些研究表明，表面CD 74的功能作为一种生存受体。
CD74 is an integral membrane protein that was thought to function mainly as an MHC class 11 chaperone. However, CD74 was recently shown to have a role as an accessory-signaling molecule. Our studies demonstrated that CD74 regulates B-cell differentiation by inducing a pathway leading to the activation of transcription mediated by the NF-kappa B p65/RelA homodimer and its coactivator, TAF(vertical bar vertical bar)105. Here, we show that CD74 stimulation with anti-CD74 antibody leads to an induction of a signaling cascade resulting in NF-kappa B activation, entry of the stimulated cells into the S phase, elevation of DNA synthesis, cell division, and augmented expression of BCL-XL. These studies therefore demonstrate that surface CD74 functions as a survival receptor.