Epidemiology of Exfoliation Syndrome.
Epidemiology of Exfoliation Syndrome.
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DOI：
10.1097/ijg.0000000000000908
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发表时间：
2018-07-01
影响因子：
2
通讯作者：
Ringvold, Amund
中科院分区：
文献类型：
--
作者：
Konstas, Anastasios G P;Ringvold, Amund
背景技术背景：从历史的角度来看，剥脱综合征（XFS）的流行病学是眼科文献中最有争议的主题之一。目前的文献中有大量关于XFS在不同种族人群中患病率的研究，显然XFS是一种常见的疾病，但其真正的患病率很难确定。总体而言，XFS被认为是最常见的可识别的原因青光眼worldwide.Purpose：本审查严格审查已发表的文献记载的流行病学特征的XFS，并试图提供一个统一的概念，关于现有的controversial.METHODS：一个关键的审查选定的文献有关的流行病学XFS。众所周知，XFS和随之而来的剥脱性青光眼在世界范围内普遍存在，并且与年龄相关的发病率逐渐增加。这种疾病的发病率被大大低估了。过去的许多研究都提出了种族群体内部和之间的明显地理差异。相反，也有一些流行病学证据表明，XFS的患病率在不同种族群体中是相似的。已发表的文献未能解决可疑剥脱病例在报告的患病率数据中的潜在作用和影响。这种情况的发病率数字有限，而且变化很大。累积的数据表明，一些，尚未部分了解遗传，种族和环境因素的不同患病率的这种conditions.CONCLUSIONS：进一步了解XFS流行病学是必要的。只有未来由相同的研究者进行的大型前瞻性研究，使用不同种族人群的类似方法，才能毫无疑问地证明存在显著地理差异的假设。由于剥脱性青光眼患者有显著的视力丧失风险，因此阐明发生XFS的原因和风险至关重要。为了达到这个目标，重要的是要更好地描述XFS的早期变化，并将研究工作集中在XFS开发的可修改因素上。
BACKGROUND: From a historical standpoint the epidemiology of exfoliation syndrome (XFS) is one of the most controversial subjects in ophthalmic literature. Current literature abounds with studies on the prevalence of XFS in various ethnic populations and clearly XFS is a common condition, but its true prevalence is difficult to ascertain. Overall, XFS is considered to be the most common identifiable cause of glaucoma worldwide.PURPOSE: This review critically examines the published literature documenting the epidemiological features of XFS and attempts to provide a unified concept concerning existing controversy.METHODS: A critical review of selected literature pertaining to the epidemiology of XFS.RESULTS: It is well established that XFS and the ensuing exfoliative glaucoma have a worldwide prevalence and a progressively increasing age-related incidence. The prevalence of the condition is significantly underestimated. Many past studies have proposed clear geographic variations within and between ethnic groups. In contrast, there has also been some epidemiological evidence suggesting that the prevalence of XFS is similar within various ethnic groups. Published literature fails to address the potential role and impact of suspected exfoliation cases in the reported prevalence figures of the condition. Incidence figures for the condition are limited and vary extensively. Cumulative data have indicated that several, as yet partly understood genetic, ethnic, and environmental factors contribute to the varied prevalence of this condition.CONCLUSIONS: Further understanding on XFS epidemiology is needed. Only a future large prospective study conducted by the same investigators, using similar methodologies for different ethnic populations will prove beyond doubt the hypothesis that significant geographic variations exist. Since patients with exfoliative glaucoma are at significant risk of losing vision it is vital to elucidate the causes and the risk of developing XFS. To reach this goal, it is important to better delineate the early changes of XFS and to focus research efforts on modifiable factors for XFS development.