Effects of Fructose or Glucose on Circulating ApoCIII and Triglyceride and Cholesterol Content of Lipoprotein Subfractions in Humans
Effects of Fructose or Glucose on Circulating ApoCIII and Triglyceride and Cholesterol Content of Lipoprotein Subfractions in Humans
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DOI：
10.3390/jcm8070913
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发表时间：
2019-07-01
影响因子：
3.9
通讯作者：
Stanhope, Kimber L.
中科院分区：
文献类型：
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作者：
Hieronimus, Bettina;Griffen, Steven C.;Stanhope, Kimber L.
ApoCIII和富含甘油三酯（TG）的脂蛋白（TRL），特别是富含TG的大脂蛋白颗粒，已被描述为心血管疾病（CVD）风险的重要介质。与持续摄入葡萄糖相比，持续摄入果糖对循环apoCIII和大TRL颗粒的影响尚未报道。我们测量了在男性和女性（年龄：54 +/- 8岁）饮用葡萄糖或果糖甜味饮料10周前后采集的空腹和餐后血浆中按大小分离的脂蛋白亚组分的apoCIII浓度和TG和胆固醇含量。与摄入葡萄糖的受试者相比，摄入果糖的受试者表现出更高的空腹和餐后血浆apoCIII浓度（两者均为p < 0.05）。在所有TRL亚组分中，他们的餐后TG浓度也较高（p < 0.05，糖的影响），最大的TRL颗粒中出现最高的增加（果糖线性趋势p < 0.0001）。与葡萄糖消耗相比，果糖消耗增加了低密度脂蛋白（LDL）颗粒中的餐后TG（p < 0.05，糖的影响），尤其是在较小的颗粒中（p < 0.0001，果糖线性趋势）。大TRL亚组分中餐后apoCIII和TG的增加与果糖诱导的较小LDL颗粒中空腹胆固醇的增加有关。总之，与葡萄糖消耗相比，10周的果糖消耗增加了循环apoCIII和大TRL颗粒的餐后浓度。
ApoCIII and triglyceride (TG)-rich lipoproteins (TRL), particularly, large TG-rich lipoproteins particles, have been described as important mediators of cardiovascular disease (CVD) risk. The effects of sustained consumption of dietary fructose compared with those of sustained glucose consumption on circulating apoCIII and large TRL particles have not been reported. We measured apoCIII concentrations and the TG and cholesterol content of lipoprotein subfractions separated by size in fasting and postprandial plasma collected from men and women (age: 54 +/- 8 years) before and after they consumed glucose- or fructose-sweetened beverages for 10 weeks. The subjects consuming fructose exhibited higher fasting and postprandial plasma apoCIII concentrations than the subjects consuming glucose (p < 0.05 for both). They also had higher concentrations of postprandial TG in all TRL subfractions (p < 0.05, effect of sugar), with the highest increases occurring in the largest TRL particles (p < 0.0001 for fructose linear trend). Compared to glucose consumption, fructose consumption increased postprandial TG in low-density lipoprotein (LDL) particles (p < 0.05, effect of sugar), especially in the smaller particles (p < 0.0001 for fructose linear trend). The increases of both postprandial apoCIII and TG in large TRL subfractions were associated with fructose-induced increases of fasting cholesterol in the smaller LDL particles. In conclusion, 10 weeks of fructose consumption increased the circulating apoCIII and postprandial concentrations of large TRL particles compared with glucose consumption.