Effects of Post-transplant Enteral Nutrition with an Immunomodulating Diet Containing Hydrolyzed Whey Peptide after Liver Transplantation
Effects of Post-transplant Enteral Nutrition with an Immunomodulating Diet Containing Hydrolyzed Whey Peptide after Liver Transplantation
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肝移植后肠内营养与含有水解乳清肽的免疫调节饮食的影响
DOI：
10.1007/s00268-012-1529-9
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发表时间：
2012
期刊：
影响因子：
2.6
通讯作者：
Yagi S(5人略6番目)
中科院分区：
文献类型：
--
作者：
Kaido T;Yagi S(5人略6番目)
摘要背景包括菌血症在内的感染引起的并发症通常发生在肝移植(LT)后，是最常见的院内死亡原因。乳清水解肽(HWP)是一种从牛奶中提取的蛋白质复合体，具有抗炎作用。本研究回顾分析了活体供肝移植(LDLT)后应用新型免疫调节饮食(IMD)进行早期肠内营养的效果。方法对2009年9月至2011年3月在我所接受LDLT的76例成人患者的临床资料进行回顾性分析。40例患者(HWP组)和36例(对照组)患者在术后24 h内分别经肠内给予含HWP的新型IMD和常规基础饮食。HWP组菌血症发生率(15%)明显低于对照组(47%)(P=0.002)。HWP组的院内感染死亡率略低于对照组，但差异无统计学意义(p=0.145)。HWP组术后第7天的空腹血糖水平显著低于对照组(P=0.005)。两组急性细胞排斥反应发生率相似(p=0.858)。结论早期肠内营养可预防移植后菌血症和高血糖，而不增加急性细胞排斥反应的发生率。
AbstractBackgroundComplications due to infections, including bacteremia, often arise after liver transplantation (LT) and are the most frequent causes of in‐hospital death. Hydrolyzed whey peptide (HWP), a protein complex derived from milk, has anti‐inflammatory effects. The present study retrospectively analyzes the effects of early enteral nutrition with a new immunomodulating diet (IMD) enriched with HWP in patients after living‐donor LT (LDLT).MethodsData from 76 consecutive adult patients who underwent LDLT at our institute between September 2009 and March 2011 were retrospectively analyzed. The new IMD enriched with HWP and a conventional elemental diet were administered enterally to 40 (HWP group) and 36 (control group) patients, respectively, within the first 24 h after surgery.ResultsThe characteristics of patients and surgical parameters did not differ between the two groups. The incidence of bacteremia was significantly lower in the HWP (15%) than in the control group (47%) (p= 0.002). The in‐hospital mortality due to infection was a little lower in the HWP group than in the control group, although there was no statistical difference (p= 0.145). The fasting blood glucose level at postoperative day 7 was significantly lower in the HWP group than in the control group (p= 0.005). The incidence of acute cellular rejection was similar between the two groups (p= 0.858).ConclusionEarly enteral nutrition with the new IMD enriched with HWP can prevent post‐transplant bacteremia and post‐transplant hyperglycemia without increasing the incidence of acute cellular rejection.
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术中严重高血糖与肝移植后手术部位感染独立相关
影响因子：
6.2
作者：
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DOI：
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发表时间：
2003
期刊：
Transplantation 76
影响因子：
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作者：
Ito T;Kiuchi T;Egawa H;Kaihara S;Oike F;Ogura Y;Fujimoto Y;et al.
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影响因子：
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作者：
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影响因子：
6.2
作者：
Inomata, Y;Tanaka, K;Hashida, T
通讯作者：
Hashida, T