DECREASED E-CADHERIN EXPRESSION IN ENDOMETRIAL CARCINOMA IS ASSOCIATED WITH TUMOR DEDIFFERENTIATION AND DEEP MYOMETRIAL INVASION
DECREASED E-CADHERIN EXPRESSION IN ENDOMETRIAL CARCINOMA IS ASSOCIATED WITH TUMOR DEDIFFERENTIATION AND DEEP MYOMETRIAL INVASION
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DOI：
10.1006/gyno.1994.1113
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发表时间：
1994-05-01
影响因子：
4.7
通讯作者：
FUJIMOTO, S
中科院分区：
文献类型：
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作者：
SAKURAGI, N;NISHIYA, M;FUJIMOTO, S
已经表明肿瘤细胞中E-钙粘蛋白表达的降低促进肿瘤侵袭。我们研究了E-cadherin的表达在30例子宫内膜癌的免疫组化使用单克隆抗体E-cadherin，并探讨其与其他组织病理学特征的肿瘤。我们注意到：（1）E-cadherin表达随分化程度的降低而降低E-cadherin表达与肌层浸润深度呈负相关（P < 0.05）（3）E-cadherin表达降低与腹主动脉旁淋巴结转移有关（P < 0.01）;（4）多因素分析比较子宫肌层浸润深度与E-钙粘蛋白表达模式、组织学分级、核分级子宫肌层浸润深度与E-cadherin表达的降低密切相关（P < 0.005）。这些发现似乎与由于E-cadherin表达减少而导致癌细胞解离促进肿瘤细胞侵袭的概念一致。(C)1994年出版社出版。
Decreased E-cadherin expression in tumor cells has been suggested to promote tumor invasiveness. We examined E-cadherin expression in 30 cases of endometrial carcinoma by immunohistochemistry using a monoclonal antibody to E-cadherin and investigated its correlation with other histopathologic features of the tumor. We observed that: (1) E-cadherin expression decreased with toss of differentiation (P < 0.05); (2) E-cadherin expression was inversely correlated with depth of myometrial invasion (P < 0.05); (3) decreased E-cadherin expression was correlated with paraaortic node metastasis (P < 0.01); and (4) multivariate analysis comparing the depth of myometrial invasion to the pattern of E-cadherin expression, histologic grade, nuclear grade, and lymph-vascular space invasion showed that the depth of myometrial invasion was most strongly correlated with decreased E-cadherin expression (P < 0.005). These findings seem to be consistent with the concept that the dissociation of cancer cells due to decreased expression of E-cadherin facilitates invasion of tumor celts. (C) 1994 Academic Press, Inc.