Effects of airborne particulate matter on respiratory morbidity in asthmatic children.
Effects of airborne particulate matter on respiratory morbidity in asthmatic children.
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DOI：
10.2188/jea.je2007432
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发表时间：
2008
影响因子：
4.7
通讯作者：
Nishimuta T
中科院分区：
文献类型：
--
作者：
Ma L;Shima M;Yoda Y;Yamamoto H;Nakai S;Tamura K;Nitta H;Watanabe H;Nishimuta T
空气中颗粒物 (PM) 的影响是人类健康的一个主要问题。在这项小组研究中，我们评估了接触 PM 对儿童呼气峰流量 (PEF) 和喘息的急性影响。对在日本郊区住院约 5 个月的 19 名哮喘儿童进行每日 PEF 和喘息检查。在医院附近的监测站监测直径小于 2.5 微米的颗粒物 (PM2.5) 浓度。此外，使用激光二极管粉尘监测仪（PM2.5（LD））测量医院内外的PM2.5浓度。分析了与 PM 浓度相关的 PEF 和喘息变化。早上和晚上 PEF 的变化与测量前 24 小时室内 PM2.5(LD) 平均浓度的增加显着相关（增加 10 µg/m3 时，分别为 -2.86 L/min [95%CI: -4.12, -1.61] 和 -3.59 L/min [95%CI: -4.99, -2.20]）。 PEF的变化也与室外PM2.5(LD)浓度显着相关，但变化小于室内PM2.5(LD)观察到的变化。 PEF 的变化和固定地点 PM2.5 的浓度没有关联。早晨和晚上喘息的发生率也与室内 PM2.5(LD) 浓度显着相关（对于 10 µg/m3 的增加，比值比分别 = 1.014 [95%CI: 1.006, 1.023] 和 1.025 [95%CI: 1.013, 1.038]）。夜间喘息与室外 PM2.5(LD) 浓度显着相关。即使在调整环境二氧化氮浓度后，室内和室外 PM2.5(LD) 的影响仍然显着。室内和室外 PM2.5(LD) 浓度与哮喘儿童的 PEF 和喘息相关。室内PM2.5(LD)比室外PM2.5(LD)或固定场所PM2.5的影响更显着。
The effects of airborne particulate matter (PM) are a major human health concern. In this panel study, we evaluated the acute effects of exposure to PM on peak expiratory flow (PEF) and wheezing in children. Daily PEF and wheezing were examined in 19 asthmatic children who were hospitalized in a suburban city in Japan for approximately 5 months. The concentrations of PM less than 2.5 µm in diameter (PM2.5) were monitored at a monitoring station proximal to the hospital. Moreover, PM2.5 concentrations inside and outside the hospital were measured using the dust monitor with a laser diode (PM2.5(LD)). The changes in PEF and wheezing associated with PM concentration were analyzed. The changes in PEF in the morning and evening were significantly associated with increases in the average concentration of indoor PM2.5(LD) 24 h prior to measurement (-2.86 L/min [95%CI: -4.12, -1.61] and -3.59 L/min [95%CI: -4.99, -2.20] respectively, for 10-µg/m3 increases). The change in PEF was also significantly associated with outdoor PM2.5(LD) concentrations, but the changes were smaller than those observed for indoor PM2.5(LD). Changes in PEF and concentration of stationary-site PM2.5 were not associated. The prevalence of wheezing in the morning and evening were also significantly associated with indoor PM2.5(LD) concentrations (odds ratios = 1.014 [95%CI: 1.006, 1.023] and 1.025 [95%CI: 1.013, 1.038] respectively, for 10-µg/m3 increases). Wheezing in the evening was significantly associated with outdoor PM2.5(LD) concentration. The effects of indoor and outdoor PM2.5(LD) remained significant even after adjusting for ambient nitrogen dioxide concentrations. Indoor and outdoor PM2.5(LD) concentrations were associated with PEF and wheezing among asthmatic children. Indoor PM2.5(LD) had a more marked effect than outdoor PM2.5(LD) or stationary-site PM2.5.