Innate immune pattern recognition: a cell biological perspective.
Innate immune pattern recognition: a cell biological perspective.
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DOI：
10.1146/annurev-immunol-032414-112240
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发表时间：
2015
影响因子：
29.7
通讯作者：
Kagan JC
中科院分区：
文献类型：
--
作者：
Brubaker SW;Bonham KS;Zanoni I;Kagan JC
先天免疫系统的受体检测微生物和病毒来源的保守决定簇。这些受体的激活启动信号传导事件，最终导致有效的免疫应答。最近，先天免疫信号传导事件依赖于复杂的细胞基础结构并在其中运作的观点已成为理解先天免疫调节的重要框架。这种基础结构中的区室化为细胞提供了将空间信息分配给微生物检测和调节免疫反应的能力。几种细胞生物学过程在先天信号应答的调节中发挥作用;同时，先天信号可以参与细胞过程作为防御或促进免疫记忆的形式。在这篇综述中，我们强调了这些方面的细胞生物学模式识别受体信号，集中在信号，起源于细胞表面，从内体车厢，从胞质内。
Receptors of the innate immune system detect conserved determinants of microbial and viral origin. Activation of these receptors initiates signaling events that culminate in an effective immune response. Recently, the view that innate immune signaling events rely on and operate within a complex cellular infrastructure has become an important framework for understanding the regulation of innate immunity. Compartmentalization within this infrastructure provides the cell with the ability to assign spatial information to microbial detection and regulate immune responses. Several cell biological processes play a role in the regulation of innate signaling responses; at the same time, innate signaling can engage cellular processes as a form of defense or to promote immunological memory. In this review, we highlight these aspects of cell biology in pattern-recognition receptor signaling by focusing on signals that originate from the cell surface, from endosomal compartments, and from within the cytosol.
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影响因子：
4.8
作者：
Chiang, Chih-Yuan;Veckman, Ville;David, Michael
通讯作者：
David, Michael
影响因子：
64.8
作者：
Alexopoulou, L;Holt, AC;Flavell, RA
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Flavell, RA
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影响因子：
30.5
作者：
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通讯作者：
Superti-Furga, Giulio
影响因子：
7.8
作者：
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通讯作者：
Podolsky, DK