Uric acid concentrations in early pregnancy among preeclamptic women with gestational hyperuricemia at delivery
Uric acid concentrations in early pregnancy among preeclamptic women with gestational hyperuricemia at delivery
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DOI：
10.1016/j.ajog.2005.06.066
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发表时间：
2006-01-01
影响因子：
9.8
通讯作者：
Roberts, JM
中科院分区：
文献类型：
--
作者：
Powers, RW;Bodnar, LM;Roberts, JM
目的：我们研究了妊娠期高尿酸血症妇女分娩时血清尿酸的变化，并与正常孕妇和无妊娠期高尿酸血症的先兆子痫妇女进行了比较。研究设计：这是一项巢式病例对照研究，包括116名对照，27名先兆子痫伴分娩前高尿酸血症的妇女，37名先兆子痫不伴分娩前高尿酸血症的妇女，35例妊娠期高血压合并高尿酸血症，但无蛋白尿。血清尿酸和肌酐测量整个pregnancy.Results：妇女分娩前高尿酸血症，与和没有先兆子痫，有增加的尿酸浓度在整个怀孕期间与对照组相比，225周的妊娠后，与妇女相比，先兆子痫没有分娩前高尿酸血症。调整肾小球滤过的差异，血清肌酐占部分，但不是全部的血清尿酸的增加，在妇女先兆子痫和predelivery hyperuricemia.Conclusions：在分娩时高尿酸血症的妇女，尿酸升高发生在早期。多种机制可能导致尿酸升高，包括肾功能变化。(c)2006 Mosby，Inc. All rights reserved.
Objective: We investigated changes in serum uric acid across pregnancy in women with gestational hyperuricemia at delivery, with and without preclampsia, compared with normal pregnant and women with preeclampsia without gestational hyperuricemia.Study design: This was a nested case-control study of 116 controls, 27 women with preeclampsia with predelivery hyperuricemia, 37 women with preeclampsia without predelivery hyperuricemia, and 35 women with gestational hypertension with hyperuricemia at delivery but without proteinuria. Serum uric acid and creatinine was measured across pregnancy.Results: Women with predelivery hyperuricemia, with and without preeclampsia, had increased uric acid concentrations across pregnancy compared with controls, after 225 weeks' gestation compared with women with preeclampsia without predelivery hyperuricemia. Adjusting for differences in glomerular filtration by serum creatinine accounted for part but not all of the increase in serum uric acid among women with preeclampsia and predelivery hyperuricemia.Conclusions: Among women with hyperuricemia at delivery, elevations in uric acid occur early. Multiple mechanisms may contribute to increased uric acid including changes in renal function. (c) 2006 Mosby, Inc. All rights reserved.