Hypothermic response produced by manassantin A, a novel neuroleptic agent.
Hypothermic response produced by manassantin A, a novel neuroleptic agent.
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Manassantin A（一种新型精神安定剂）产生的低温反应。
DOI：
10.1016/0024-3205(88)90248-2
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发表时间：
1988
期刊：
影响因子：
6.1
通讯作者：
Puri,VN
中科院分区：
文献类型：
--
作者：
Rao,KV;Puri,VN
马纳桑汀A （Manassantin A, MNS-A）是一种新型的神经性中性化合物，经脑室注射（icv）、（0.1、1.0、3.2、10 μgg/只）、腹腔注射（ip）、（0.1、0.32、1.0、3.2 mg/kg）和口服（0.5、1.6、5.0、16 mg/kg）给药后，可引起CD-1株雌雄小鼠的低温反应。结果表明，低温与剂量和时间有关，icv方法在2 h后体温下降幅度最大（P<0.001）。然而，低、中剂量的ip和口服不是很有效，但高剂量引起体温显著降低（P<0.001）。MNS-A中枢诱导的低温反应可能为抗抑郁药物的筛选模型提供未来的线索，并且可以成为操纵生理和药理学过程以了解中枢体温调节功能的有用工具。
Manassantin A (MNS-A), a novel neolignoid, neutral compound shown to possess neuroleptic properties, causes hypothermic response in male and female mice of CD-1 strain when administered by the intracerebroventricular (icv), (0.1, 1.0, 3.2, 10 μgg/mouse), intraperitoneal (ip), (0.1, 0.32, 1.0, 3.2 mg/kg) and oral (0.5, 1.6, 5.0, 16 mg/kg) routes. The hypothermia was found to be dose and time dependent, the maximum decrease of temperature being observed by the icv route (P<0.001) after 2 hours. However, ip and oral administration of lower and middle order doses were not very effective but higher doses caused significant (P<0.001) reduction of body temperature. The centrally-induced hypothermic response by MNS-A may give future leads as a screening model for antidepressant drugs and can be a useful tool for manipulating physiological and pharmacological processes to understand the central thermoregulatory functions.