Increased sensitivity to food cues in the fasted state and decreased inhibitory control in the satiated state in the overweight
Increased sensitivity to food cues in the fasted state and decreased inhibitory control in the satiated state in the overweight
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DOI：
10.3945/ajcn.112.044024
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发表时间：
2013-03-01
影响因子：
7.1
通讯作者：
Westerterp-Plantenga, Margriet S.
中科院分区：
文献类型：
--
作者：
Martens, Mieke J. I.;Born, Juriaan M.;Westerterp-Plantenga, Margriet S.
背景资料：食物和非食物刺激之间的食物奖励相关脑信号（FRS）的灵活性可能在超重和正常体重受试者之间存在差异，并取决于禁食或饱足状态。目的：目的是评估这种灵活性对视觉食物和非食物线索的反应。设计：20个正常体重[平均值+/- SEM BMI（kg/m2）= 22.7 +/- 0.2;平均+/- SEM年龄= 22.4 +/- 0.4岁]和20名超重（BMI = 28.1 +/- 0.3;年龄= 24.0 +/- 0.7岁）参与者完成了2次fMRI扫描。受试者在空腹状态下到达，并在2次连续扫描之间食用由20%的受试者特定能量需求组成的早餐。结果：在前扣带皮层（ACC）（P < 0.006，F-（1，F-38）= 9.12）和右侧壳核（P <0.006，F-（1，F-38）= 9.27）观察到了总体刺激×条件×受试者组效应。在所有参与者中，扣带回（P < 0.005，t（（39））= 3.15）和右前额叶皮质（PFC）（P < 0.006，t（（39））= 3.00）的FRS从禁食状态下降到饱足状态。在禁食状态下，他们在PFC中显示FRS（P < 0.004，t（（39））= 3.17），左心室（P < 0.009，t（39）= 2.95），右室肥厚扣带皮层（P <0.004，t（39））= 3.21），丘脑（P <0.006，t（39））= 2.96）。在饱足状态下，FRS仅限于左侧额叶皮层（P < 0.005，t（39））= 3.21）、右侧额叶皮层（P < 0.006，t（39））= 3.04）和扣带皮层（P < 0.005，t（39））= 3.15）。关于受试者组，在空腹状态下，ACC中的FRS在超重受试者中比在正常体重受试者中更明显（P < 0.005，F-（1，F-38）= 9.71），而在饱足状态下，在ACC中，超重受试者的FRS比正常体重受试者的FRS更不明显。（P < 0.006，F-（1，F-38）= 9.18）和PFC（P < 0.006，F-（1，F-38）= 8.86），表明超重者抑制控制能力较低。结论：超重者在饱足状态下FRS较高，而在充分饱足状态下抑制控制信号较低，易导致暴饮暴食。该试验在荷兰临床试验注册中心注册为NTR 2174。Ant J Clin Nutr 2013;97：471-9.
Background: Flexibility of food reward related brain signaling (FRS) between food and nonfood stimuli may differ between overweight and normal-weight subjects and depend on a fasted or satiated state.Objective: The objective was to assess this flexibility in response to visual food and nonfood cues.Design: Twenty normal-weight [mean +/- SEM BMI (in kg/m(2)) = 22.7 +/- 0.2; mean +/- SEM age = 22.4 +/- 0.4 y] and 20 overweight (BMI = 28.1 +/- 0.3; age = 24.0 +/- 0.7 y) participants completed 2 fMRI scans. Subjects arrived in a fasted state and consumed a breakfast consisting of 20% of subject-specific energy requirements between 2 successive scans. A block paradigm and a food > nonfood contrast was used to determine FRS.Results: An overall stimulus x condition x subject group effect was observed in the anterior cingulate cortex (ACC) (P < 0.006, F-(1,F-38) = 9.12) and right putamen (P < 0.006, F-(1,F-38) = 9.27). In all participants, FRS decreased from the fasted to the satiated state in the cingulate (P < 0.005, t((39)) = 3.15) and right prefrontal cortex (PFC) (P < 0.006, t((39)) = 3.00). In the fasted state, they showed FRS in the PFC (P < 0.004, t((39)) = 3.17), left insula (P < 0.009, t((39)) = 2.95), right insula (P < 0.005, t((39)) = 3.12), cingulate cortex (P < 0.004, t((39)) = 3.21), and thalamus (P < 0.006, t((39)) = 2.96). In the satiated state, FRS was limited to the left insula (P < 0.005, t((39)) = 3.21), right insula (P < 0.006, t((39)) = 3.04), and cingulate cortex (P < 0.005, t((39)) = 3.15). Regarding subject group, in the fasted state, FRS in the ACC was more pronounced in overweight than in normal-weight subjects (P < 0.005, F-(1,F-38) = 9.71), whereas in the satiated state, FRS was less pronounced in overweight than in normal-weight subjects in the ACC (P < 0.006, F-(1,F-38) = 9.18) and PFC (P < 0.006, F-(1,F-38) = 8.86), which suggests lower inhibitory control in the overweight.Conclusion: FRS was higher in the overweight in the satiated state; however, when sufficiently satiated, the overweight showed decreased inhibitory control signalling, which facilitates overeating. This trial was registered in the Dutch clinical trial register as NTR2174. Ant J Clin Nutr 2013;97:471-9.