Neurological and psychiatric predictors of mortality in patients with Alzheimer disease in California
Neurological and psychiatric predictors of mortality in patients with Alzheimer disease in California
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DOI：
10.1001/archneur.1997.00550190066016
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发表时间：
1997-07-01
影响因子：
--
通讯作者：
Kraemer, HC
中科院分区：
文献类型：
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作者：
Moritz, DJ;Fox, PJ;Kraemer, HC
目的：确定神经和精神症状是否预测阿尔茨海默病（AD）患者在调整社会人口学变量、健康状况和痴呆严重程度的影响后的生存时间。设计：样本由936名男性和女性组成，这些男性和女性在加州的7个阿尔茨海默病诊断和治疗中心中的一个被诊断为可能或可能患有AD。从1986年到1990年。在AD诊断时收集关于痴呆严重程度、共病情况和人口统计学特征的数据。通过将患者档案与由加州州和联邦政府维护的几个管理数据库相连接，获得了关于生命状态和死亡日期的数据。平均随访时间为31个月。采用Kaplan-Meier生存曲线和考克斯比例风险模型对数据进行分析。
Objective: To determine whether neurological and psychiatric symptoms predict survival time among patients with Alzheimer disease (AD) after adjusting for the influence of sociodemographic variables, health conditions, and dementia severity separately for men and women.Design: The sample consisted of 936 men and women diagnosed as having probable or possible AD at 1 of 7 Alzheimer's Disease Diagnostic and Treatment Centers throughout California from 1986 through 1990. Data on dementia severity, comorbid conditions, and demographic characteristics were collected at the time of AD diagnosis. Data on vital status and dates of death were obtained by linking the patient file Co several administrative databases maintained by the California State and federal governments. The mean length of follow-up was 31 months. Data were analyzed with Kaplan-Meier survival curves and Cox proportional hazards models.Results: Men had shorter survival times than did women (log-rank test, 30.93, P