Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis
Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis
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睡眠中断是阿尔茨海默病的危险因素吗？
DOI：
10.1101/609834
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Anderson E
中科院分区：
文献类型：
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作者：
Anderson E
简介 众所周知，阿尔茨海默病 (AD) 患者会经历睡眠中断。然而，睡眠数量、质量或时间的中断是否是 AD 发病的危险因素仍不清楚。方法使用孟德尔随机化 (MR) 来估计自我报告和加速计测量的睡眠参数（时间型、持续时间、碎片化、失眠、白天小睡和白天嗜睡）对 AD 风险的因果影响。结果总体而言，几乎没有证据表明睡眠特征会影响 AD 风险。有一些证据表明，自我报告的白天小睡与较低的 AD 风险相关（比值比 [OR]：0.70，95% 置信区间 [CI]：0.50 至 0.99）。其他一些睡眠特征（加速计测量的晚间睡眠时间和睡眠持续时间，以及自我报告的白天嗜睡）对于 AD 风险的 OR 值与白天小睡的程度相似，但估计不太精确。讨论我们的研究结果提供了初步证据，表明白天小睡可能会降低 AD 风险。然而，研究结果应该使用独立样本来重复。
INTRODUCTIONIt is established that Alzheimer’s disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset of AD.METHODSMendelian randomization (MR) was used to estimate the causal effect of self-reported and accelerometer-measured sleep parameters (chronotype, duration, fragmentation, insomnia, daytime napping and daytime sleepiness) on AD risk.RESULTSOverall, there was little evidence that sleep traits affect the risk of AD. There was some evidence to suggest that self-reported daytime napping was associated with lower AD risk (odds ratio [OR]: 0.70, 95% confidence interval [CI]: 0.50 to 0.99). Some other sleep traits (accelerometer-measured eveningness and sleep duration, and self-reported daytime sleepiness) had ORs for AD risk of a similar magnitude to daytime napping, but were less precisely estimated.DISCUSSONOur findings provide tentative evidence that daytime napping may reduce AD risk. However, findings should be replicated using independent samples.