Outdoor exposure to airborne polycyclic organic matter and adverse reproductive outcomes: A pilot study
Outdoor exposure to airborne polycyclic organic matter and adverse reproductive outcomes: A pilot study
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DOI：
10.1002/ajim.1096
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发表时间：
2001-09-01
影响因子：
3.5
通讯作者：
Klotz, JB
中科院分区：
文献类型：
--
作者：
Vassilev, ZP;Robson, MG;Klotz, JB
研究新泽西室外空气中多环有机物（POM）与不良生殖结果之间的关系;我们使用了一个横断面设计，结合了来自丽莎EPA累积暴露项目的空气质量数据和来自人口普查区域水平的出生和胎儿死亡证明的怀孕结果的个体数据。方法在排除多胎分娩和染色体异常后，221，406例活产婴儿和1例，包括1990年和1991年期间在新泽西登记的591例胎儿死亡。暴露估计来自建模的平均POM浓度为每个人口普查tract.Results调整后的潜在混杂因素，比值比（OR）为极低出生体重的最高暴露组相比，最低暴露组为1.31（95% CI 1.15-1.51）;在足月分娩中，高POM暴露与低出生体重相关，OR = 1.31（95% CI 1.21-1.43），胎儿死亡OR = 1.19（95% CI 1.02-1.39），早产OR = 1.25（95% CI 1.19-1.31）。单变量分层分析表明，所有观察到的协会由产妇酒精consumption.Conclusions影响修改本研究发现户外暴露建模平均空气中POM和几个不良妊娠结局之间的关联。这项试验性研究所采用的数据和方法，可能有助于确定需要深入调查的有害空气污染物。(C)2001 Wiley-Liss，Inc.
Background To investigate the association between outdoor airborne polycyclic organic matter(POM) and adverse reproductive outcomes in New Jersey; we used a cross-sectional design combining air quality data from the LISA EPA Cumulative Exposure Project and individual data on pregnancy outcomes from birth and fetal death certificates at the census tract level.Methods After excluding plural births and chromosomal anomalies, 221,406 live births and 1,591 fetal deaths registered in New Jersey during the years of 1990 and 1991 were included. The exposure estimates were derived from modeled average POM concentrations for each census tract in the state.Results After adjustment for potential confounders, the odds ratios (OR) for very low birth weight for the highest exposure compared to the lowest exposure group was 1.31 (95% CI 1.15-1.51); among term births, high POM exposure was associated with low birth weight OR = 1.31 (95% CI 1.21-1.43), with fetal death OR = 1.19 (95% CI 1.02-1.39) and with premature birth OR = 1.25 (95% CI 1.19-1.31). The univariate stratified analyses suggested effect modification of all observed associations by maternal alcohol consumption.Conclusions This study found associations between outdoor exposure to modeled average airborne POM and several adverse pregnancy outcomes. The data and methods utilized in this pilot study may be useful for identifying hazardous air pollutants requiring in-depth investigation. (C) 2001 Wiley-Liss, Inc.