Type 2 diabetes in hepatitis C-related mixed cryoglobulinaemia patients
Type 2 diabetes in hepatitis C-related mixed cryoglobulinaemia patients
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DOI：
10.1093/rheumatology/keh011
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发表时间：
2004-02-01
期刊：
影响因子：
5.5
通讯作者：
Ferrannini, E
中科院分区：
文献类型：
--
作者：
Antonelli, A;Ferri, C;Ferrannini, E
目标。混合性冷球蛋白血症（MC）是一种系统性血管炎，通常与丙型肝炎病毒（HCV）感染有关。丙型肝炎病毒感染与2型糖尿病之间可能存在联系。本研究评估了MC-HCV+患者糖尿病的患病率和临床表型。229名连续招募的MC-HCV阳性患者与217名性别和年龄匹配的未感染HCV的对照组进行比较。MC-HCV+组2型糖尿病患病率明显高于对照组（14.4% vs 6.9%, P < 0.01）。MC-HCV阳性的糖尿病患者比无MC-HCV的糖尿病患者瘦（P < 0.0001），总脂蛋白胆固醇和低密度脂蛋白胆固醇水平显著降低（P < 0.001），收缩压（P = 0.01）和舒张压（P = 0.005）显著降低。MC-HCV+糖尿病患者非器官特异性自身抗体发生率高于非糖尿病MC-HCV+患者（34% vs 18%, P = 0.032）。2型糖尿病在MC-HCV患者中的患病率高于对照组。糖尿病MC-HCV+患者表现出较弱的糖尿病表型，并且更可能携带非器官特异性自身抗体。
Objectives. Mixed cryoglobulinaemia (MC) is a systemic vasculitis frequently associated with hepatitis C virus (HCV) infection. A possible link between HCV infection and type 2 diabetes has been suggested. This study evaluated the prevalence and clinical phenotype of diabetes in MC-HCV+ patients.Methods. Two hundred and twenty-nine consecutively recruited MC-HCV+ patients were compared with 217 sex- and age-matched controls without HCV infection.Results. The prevalence of type 2 diabetes was significantly higher in MC-HCV+ patients than in controls (14.4 vs 6.9%, P < 0.01). Diabetic MC-HCV+ patients were leaner than diabetic patients without MC-HCV (P < 0.0001), and showed significantly lower total and low-density lipoprotein cholesterol levels (P < 0.001) and lower systolic (P = 0.01) and diastolic blood pressure (P = 0.005). MC-HCV+ diabetic patients had non-organ-specific autoantibodies more frequently (34 vs 18%, P = 0.032) than non-diabetic MC-HCV+ patients.Conclusions. The prevalence of type 2 diabetes is higher in patients with MC-HCV than in controls. Diabetic MC-HCV+ patients show an attenuated diabetic phenotype and are more likely to carry non-organ-specific autoantibodies.