Serum creatinine levels and risk of nonalcohol fatty liver disease in a middle-aged and older Chinese population: A cross-sectional analysis
Serum creatinine levels and risk of nonalcohol fatty liver disease in a middle-aged and older Chinese population: A cross-sectional analysis
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DOI：
10.1002/dmrr.3489
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发表时间：
2021-09-13
影响因子：
8
通讯作者：
Su, Qing
中科院分区：
文献类型：
--
作者：
Niu, Yixin;Zhang, Weiwei;Su, Qing
背景：非酒精性脂肪性肝病（NAFLD）现在被认为是代谢综合征（MetS）的肝脏表现。最近的研究表明，血清肌酐（SCr）可能是MetS及其相关疾病的一个指标。我们的目的是调查中国成人SCr和NAFLD之间的关系。方法对8862名年龄在40岁及以上（40-73岁）的中国男性进行横断面分析。进行了人体测量、实验室检查和肝脏超声检查。在没有其他肝脏疾病的情况下，通过肝脏超声确定NAFLD的存在。结果NAFLD组SCr高于非NAFLD组（66.8 mu mol/L vs. 65.6 mu mol/L, p < 0.001）。此外，在校正潜在协变量后，SCr水平与丙氨酸转氨酶（β = 0.099, p < 0.001）、天冬氨酸转氨酶（β = 0.135, p < 0.001）、γ -谷氨酰转移酶（β = 0.039, p < 0.001）和胰岛素抵抗（β = 0.027, p = 0.014）相关。在多变量校正logistic回归分析中，与第一个SCr五分位数相比，在调整多个测量混杂因素后，第五个五分位数NAFLD的优势比为1.35（95%置信区间1.14-1.60,p < 0.001）。结论SCr浓度与中国中老年人群NAFLD独立相关。SCr水平升高，即使在正常范围内，也与NAFLD的高风险相关。
Background Non-alcoholic fatty liver disease (NAFLD) is now regarded as the hepatic manifestation of metabolic syndrome (MetS). Recent research has suggested that serum creatinine (SCr) may be an indicator of MetS and its related diseases. We aimed to investigate the association between SCr and NAFLD in Chinese adults. Methods A cross-sectional sample of 8862 subjects aged 40 years or older (40-73 years) from China were analysed in this study. The anthropometric measurements, laboratory tests, and hepatic ultrasonography were conducted. NAFLD presence was defined by hepatic ultrasound in the absence of other liver diseases. Results NAFLD subjects had higher SCr than those without NAFLD (66.8 mu mol/L vs. 65.6 mu mol/L, p < 0.001). Moreover, SCr levels were correlated with alanine aminotransferase (beta = 0.099, p < 0.001), aspartate aminotransferase (beta = 0.135, p < 0.001), gamma-glutamyltransferase (beta = 0.039, p < 0.001), and insulin resistance (beta = 0.027, p = 0.014) after adjusted for potential covariates. In the multivariable-adjusted logistic regression analyses, compared to the first SCr quintile, the odds ratio for NAFLD was 1.35 (95% confidence interval 1.14-1.60, p < 0.001) for the fifth quintile after adjusting multiple measured confounders. Conclusion SCr concentration is independently associated with NAFLD in a middle aged and older Chinese population. Elevated SCr levels, even within normal ranges, were associated with higher risk of NAFLD.