Distribution of Novel and Well-Known Poly- and Perfluoroalkyl Substances (PFASs) in Human Serum, Plasma, and Whole Blood
Distribution of Novel and Well-Known Poly- and Perfluoroalkyl Substances (PFASs) in Human Serum, Plasma, and Whole Blood
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DOI：
10.1021/acs.est.7b03299
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发表时间：
2017-11-21
影响因子：
11.4
通讯作者：
Haug, Line Smastuen
中科院分区：
文献类型：
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作者：
Poothong, Somrutai;Thomsen, Cathrine;Haug, Line Smastuen
目前，关于聚氟烷基物质(PFAS)在不同血液基质中的分布，特别是新型PFAS，如多氟烷基磷酸酯(PAPs)和全氟烷基膦酸酯(PFPA)，了解得很有限。为了探索这一点，收集了挪威奥斯陆61名成年人的血清、血浆和全血。全血中检出的PFASs最多。对于PAPs和PFPA，在血浆中的检测频率和浓度最高。PAPs占血浆中PFAS总量的8%(中位数为0.81 ng mL(-1))，全氟己基膦酸盐(PFHxPA)是主要的PFPA，与血液基质无关。全氟辛烷磺酸在血液基质中的相对组成分布不同。全氟辛烷磺酰胺(PFOSA)和全氟己酸(PFHxA)等特定的PFASs在全血中的浓度最高。全氟辛烷磺酸浓度比率因血液基质的不同而不同，具体取决于不同的化合物。然而，观察到6：2多氟烷基磷酸二酯(6：2diPAP)以及众所周知的全氟辛烷磺酸(PFOS)和全氟辛酸(PFOA)等全氟辛烷基磷酸二酯的比例相似。除了测定人体血液中的25种全氟辛烷磺酸，这项研究还有助于更好地了解来自不同血液基质的生物监测数据，这是进行暴露评估和流行病学研究的关键知识。
Currently, there is limited knowledge on the distribution of poly- and perfluoroalkyl substances (PFASs) in different blood matrices, particularly for novel PFASs such as polyfluoroalkyl phosphate esters (PAPs) and perfluoroalkyl phosphonates (PFPAs). To explore this, serum, plasma, and whole blood from 61 adults in Oslo, Norway were collected. The largest number of PFASs were detected in whole blood. For PAPs and PFPAs, the highest frequencies of detection and concentrations were observed in plasma. PAPs contributed to 8% of total PFASs in plasma (median, 0.81 ng mL(-1)) Perfluorohexylphosphonate (PFHxPA) was the dominant PFPA, regardless of blood matrix. The relative composition profiles of PFASs in blood matrices differed. For some specific PFASs such as perfluorooctanesulfonamide (PFOSA) and perfluorohexanoate (PFHxA), the highest concentrations were observed in whole blood. The PFAS concentration ratios varied between blood matrices, depending on the compounds. However, similar ratios were observed for 6:2 polyfluoroalkyl phosphate diester (6:2diPAP) as well as well-known PFASs such as perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA). Besides the determination of 25 PFASs in human blood, this study also lead to better understanding of biomonitoring data from different blood matrices, which is key knowledge for performing both exposure assessments and epidemiological studies.