The cytokine storm of severe influenza and development of immunomodulatory therapy.
The cytokine storm of severe influenza and development of immunomodulatory therapy.
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重症流感的细胞因子风暴与免疫调节治疗的发展
DOI：
10.1038/cmi.2015.74
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发表时间：
2016-01
影响因子：
24.1
通讯作者：
Yang ZQ
中科院分区：
文献类型：
--
作者：
Liu Q;Zhou YH;Yang ZQ
重症流感对人类的毒力仍然不寻常。由这些感染引起的并发症或最终死亡通常与促炎细胞因子产生的过度诱导有关，这也被称为“细胞因子风暴”。对于这种疾病，已经提出免疫调节治疗可能会改善结果，与或不与抗病毒药的组合。在这里，我们回顾了目前的文献中关于免疫系统的各种效应物如何启动细胞因子风暴和加剧宿主的病理损伤。我们还回顾了目前用于治疗严重流感中细胞因子风暴的一些免疫调节策略，包括皮质类固醇，过氧化物酶体增殖物激活受体激动剂，鞘氨醇-1-磷酸受体1激动剂，环氧合酶-2抑制剂，抗氧化剂，抗肿瘤坏死因子治疗，静脉注射免疫球蛋白治疗，他汀类药物，阿比朵尔，草药和其他潜在的治疗策略。
Severe influenza remains unusual in its virulence for humans. Complications or ultimately death arising from these infections are often associated with hyperinduction of proinflammatory cytokine production, which is also known as ‘cytokine storm'. For this disease, it has been proposed that immunomodulatory therapy may improve the outcome, with or without the combination of antiviral agents. Here, we review the current literature on how various effectors of the immune system initiate the cytokine storm and exacerbate pathological damage in hosts. We also review some of the current immunomodulatory strategies for the treatment of cytokine storms in severe influenza, including corticosteroids, peroxisome proliferator-activated receptor agonists, sphingosine-1-phosphate receptor 1 agonists, cyclooxygenase-2 inhibitors, antioxidants, anti-tumour-necrosis factor therapy, intravenous immunoglobulin therapy, statins, arbidol, herbs, and other potential therapeutic strategies.