The Pig as a Model Animal for Studying Cognition and Neurobehavioral Disorders
The Pig as a Model Animal for Studying Cognition and Neurobehavioral Disorders
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DOI：
10.1007/7854_2010_112
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发表时间：
2011-01-01
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影响因子：
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通讯作者：
van der Staay, F. Josef
中科院分区：
文献类型：
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作者：
Gieling, Elise T.;Schuurman, Teun;van der Staay, F. Josef
在实验动物研究中，较短的系统发育距离，即模型物种与待建模物种之间的高度相似性，有望增加模型物种中获得的结果的相关性和普遍性。 （小型）猪显示出多种有利特征，导致该物种在人类医学问题建模研究中的使用增加，包括神经行为（功能障碍）。例如，与小鼠或大鼠的大脑皮层不同，猪的大脑皮层具有与人类新皮层类似的大脑回旋（回旋和脑沟）。我们期望适当选择的猪模型将产生高转化价值的结果。然而，这一说法仍需要研究证实，而猪的研究领域仍处于起步阶段。本章概述了猪作为研究认知功能障碍和神经行为障碍及其治疗的模型物种，并讨论了各种测试的利弊，以帮助研究人员考虑在生物医学研究中使用猪作为模型动物物种。
In experimental animal research, a short phylogenetic distance, i.e., high resemblance between the model species and the species to be modeled is expected to increase the relevance and generalizability of results obtained in the model species. The (mini)pig shows multiple advantageous characteristics that have led to an increase in the use of this species in studies modeling human medical issues, including neurobehavioral (dys)functions. For example, the cerebral cortex of pigs, unlike that of mice or rats, has cerebral convolutions (gyri and sulci) similar to the human neocortex. We expect that appropriately chosen pig models will yield results of high translational value. However, this claim still needs to be substantiated by research, and the area of pig research is still in its infancy. This chapter provides an overview of the pig as a model species for studying cognitive dysfunctions and neurobehavioral disorders and their treatment, along with a discussion of the pros and cons of various tests, as an aid to researchers considering the use of pigs as model animal species in biomedical research.