Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug.
Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug.
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DOI：
10.1155/2012/247597
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发表时间：
2012
影响因子：
--
通讯作者：
Wei MQ
中科院分区：
文献类型：
--
作者：
Crespo-Ortiz MP;Wei MQ
选择性杀死恶性细胞的高效药物的开发将大大提高癌症患者的生活质量和生存率。青蒿素及其类似物是天然存在的抗疟药物，已显示出强大的抗癌活性。在原发性肿瘤培养物和细胞系中，它们的抗肿瘤作用是通过抑制肿瘤的增殖、转移和血管生成来实现的。在异种移植模型中，暴露于青蒿素可显著减少肿瘤体积和进展。然而，在抗癌治疗中使用青蒿素的基本原理必须通过对其细胞毒性作用的潜在机制有更深入的了解来解决。青蒿素的主要作用靶点及其对异源肿瘤细胞优先作用的化学基础尚不清楚。本文就这类潜在抗癌药物的最新进展和新发展作一综述。
Improvement of quality of life and survival of cancer patients will be greatly enhanced by the development of highly effective drugs to selectively kill malignant cells. Artemisinin and its analogs are naturally occurring antimalarials which have shown potent anticancer activity. In primary cancer cultures and cell lines, their antitumor actions were by inhibiting cancer proliferation, metastasis, and angiogenesis. In xenograft models, exposure to artemisinins substantially reduces tumor volume and progression. However, the rationale for the use of artemisinins in anticancer therapy must be addressed by a greater understanding of the underlying mechanisms involved in their cytotoxic effects. The primary targets for artemisinin and the chemical base for its preferential effects on heterologous tumor cells need yet to be elucidated. The aim of this paper is to provide an overview of the recent advances and new development of this class of drugs as potential anticancer agents.
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影响因子：
3
作者：
Chen, HH;Zhou, HJ;Wu, GD
通讯作者：
Wu, GD
影响因子：
5.3
作者：
Chen T;Li M;Zhang R;Wang H
通讯作者：
Wang H
影响因子：
7.4
作者：
Efferth, T;Benakis, A;Marschall, M
通讯作者：
Marschall, M
影响因子：
3.6
作者：
Efferth, T;Sauerbrey, A;Funk, JO
通讯作者：
Funk, JO
DOI：
10.1073/pnas.1015762108
发表时间：
2011-03-15
影响因子：
11.1
作者：
Charman, Susan A.;Arbe-Barnes, Sarah;Vennerstrom, Jonathan L.
通讯作者：
Vennerstrom, Jonathan L.