Expression of androgen receptor mRNA during mouse embryogenesis
Expression of androgen receptor mRNA during mouse embryogenesis
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DOI：
10.1016/s0925-4773(98)00007-0
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发表时间：
1998-03-01
影响因子：
2.6
通讯作者：
Blum, M
中科院分区：
文献类型：
--
作者：
Crocoll, A;Zhu, CQC;Blum, M
雄激素受体（AR）是作为配体依赖性转录因子的核受体超家族的成员（Beato，M.，Herrlich，P.，Schutz，1989年。类固醇激素受体：寻找阴谋的许多演员。Cell 83，851-857）。它在性发育和生殖中起关键作用（Wilson，J.D.，格里芬，J.E.，乔治，F.W.，Leshin，M.，1981.性腺类固醇激素在性分化中的作用。我是青蛙。霍姆Res. 37，1-39; Jest，A.，1990.荷尔蒙控制身体的男性化。在：Baulieu，E.E.，凯利地方检察官（编），激素，从分子到疾病Chapman and Hall，纽约和伦敦，pp. 439-442.）。AR序列中的突变引起许多生理病症，如部分和完全雄激素不敏感综合征，其导致异常性发育（Patterson，M.N.，McPhaul，M.J.，休斯，洛杉矶，1994.雄激素不敏感综合征。Balliere's Clin. Endocrinol. Metab. 8，379-404.）。有迹象表明，AR还可能具有其他功能。例如，AR序列的结构改变与前列腺癌有关（Visakorpi，T.，Huytinen，E.，科伊维斯托，P。，坦纳，M.，凯纳嫩河Palmberg，C.，Palotie，A.，塔梅拉，T.，Isola，J.，Kallioniemi，O. P.的人，1995.雄激素受体基因的体内扩增与人前列腺癌的进展。Nature Genet. 9，401-406.）以及在脊髓和延髓肌萎缩（一种神经变性疾病）的发展中（Kennedy，W.R.，Alter，M.，Sung，J.H.，1968.晚发性进行性近端脊髓延髓肌萎缩症：伴性隐性遗传。Neurology 18，671-680.）。在这里，我们已经调查了AR在小鼠器官发生过程中的空间和时间表达的原位杂交。我们证明，AR转录发生在发展中的外生殖器，垂体，肾上腺，肾脏和肛提肌，除了已知的表达位点在Wolffian导管及其衍生物和乳腺发育过程中。(C)1998爱思唯尔科学爱尔兰有限公司
Androgen receptor (AR) is a member of the nuclear receptor superfamily which acts as a ligand-dependent transcription factor (Beato, M., Herrlich, P., Schutz, 1989. Steroid hormone receptors: many actors in search of a plot. Cell 83, 851-857). It plays a pivotal role in sexual development and reproduction (Wilson, J.D., Griffin, J.E., George, F.W., Leshin, M., 1981. The role of gonadal steroids in sexual differentiation. Rec. Frog. Horm. Res. 37, 1-39; Jest, A., 1990. Hormonal control of the masculinization of the body. In: Baulieu, E.E., Kelly, D.A., (Eds.), Hormones, from Molecules to Disease. Chapman and Hall, New York and London, pp. 439-442.). Mutations in the AR sequence cause a number of physiological disorders, such as partial and complete androgen insensitivity syndromes, that lead to abnormal sexual development (Patterson, M.N., McPhaul, M.J., Hughes, I.A., 1994. Androgen insensitivity syndrome. Balliere's Clin. Endocrinol. Metab. 8, 379-404.). There an indications that AR may also have other functions. For example, structural alterations of the AR sequence have been implicated in prostate cancer (Visakorpi, T., Huytinen, E., Koivisto, P., Tanner, M., Keinanen, R., Palmberg, C., Palotie, A., Tammela, T., Isola, J., Kallioniemi, O.-P., 1995. In vivo amplification of the androgen receptor gene and progression of human prostate cancer. Nature Genet. 9, 401-406.) and in the development of spinal and bulbar muscular atrophy, a neurodegenerative disease (Kennedy, W.R., Alter, M., Sung, J.H., 1968. Progressive proximal spinal and bulbar muscular atrophy of late onset: a sex-linked recessive trait. Neurology 18, 671-680.). Here, we have investigated the spatial and temporal expression of AR during mouse organogenesis by in situ hybridisation. We demonstrate that AR transcripts occur in the developing external genitalia, pituitary, adrenals, kidneys and musculus levator ani, in addition to the known expression sites in the Wolffian ducts and its derivatives and during development of the mammary glands. (C) 1998 Elsevier Science Ireland Ltd.