Geographic and Genomic Distribution of SARS-CoV-2 Mutations
Geographic and Genomic Distribution of SARS-CoV-2 Mutations
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DOI：
10.3389/fmicb.2020.01800
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发表时间：
2020-07-22
影响因子：
5.2
通讯作者：
Giorgi, Federico M.
中科院分区：
文献类型：
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作者：
Mercatelli, Daniele;Giorgi, Federico M.
新型呼吸道疾病COVID-19已达到全球大流行的状态，目前正在进行大规模的努力，以分子表征引起它的病毒SARS-CoV-2。散布在地球仪各地的SARS-CoV-2标本的基因组变异性可能是地理特异性病原学效应的基础。在本研究中，我们收集了48，635个SARS-CoV-2完整的基因组，这要归功于GISAID财团和数千个贡献实验室的收集奋进。我们分析并注释了所有SARS-CoV-2突变，并与参考武汉基因组NC_045512.2进行了比较，观察到每个样本平均有7.23个突变。我们的分析显示，单核苷酸转换作为世界各地的主要突变类型的普遍性。存在至少三个分支，其特征在于地理和基因组特异性。特别是，在欧洲流行的进化枝G在刺突蛋白中携带D 614 G突变，该突变负责病毒与宿主人类细胞的初始相互作用。我们的分析可能有助于根据SARS-CoV-2在不同患者和地理位置的分子特异性定制设计的抗病毒策略。
The novel respiratory disease COVID-19 has reached the status of worldwide pandemic and large efforts are currently being undertaken in molecularly characterizing the virus causing it, SARS-CoV-2. The genomic variability of SARS-CoV-2 specimens scattered across the globe can underly geographically specific etiological effects. In the present study, we gather the 48,635 SARS-CoV-2 complete genomes currently available thanks to the collection endeavor of the GISAID consortium and thousands of contributing laboratories. We analyzed and annotated all SARS-CoV-2 mutations compared with the reference Wuhan genome NC_045512.2, observing an average of 7.23 mutations per sample. Our analysis shows the prevalence of single nucleotide transitions as the major mutational type across the world. There exist at least three clades characterized by geographic and genomic specificity. In particular, clade G, prevalent in Europe, carries a D614G mutation in the Spike protein, which is responsible for the initial interaction of the virus with the host human cell. Our analysis may facilitate custom-designed antiviral strategies based on the molecular specificities of SARS-CoV-2 in different patients and geographical locations.