Catatonic Schizophrenia: A Cohort Prospective Study
Catatonic Schizophrenia: A Cohort Prospective Study
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DOI：
10.1093/schbul/sbq087
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发表时间：
2012-03-01
影响因子：
6.6
通讯作者：
Malaspina, Dolores
中科院分区：
文献类型：
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作者：
Kleinhaus, Karine;Harlap, Susan;Malaspina, Dolores
在20世纪，紧张症通常被认为是精神分裂症的一个亚型。最近，紧张症的性质和分类正在被重新考虑。这项研究首次使用前瞻性收集的数据来描述紧张性精神分裂症，并研究了紧张性精神分裂症与其他类型精神分裂症的区别或相似之处。对9079名从出生到29-41岁的后代进行了数据分析。使用比例风险模型，计算第一次精神病院入院的时间，比较紧张性精神分裂症与“其他精神分裂症”的危险因素。568例精神分裂症中，43例（7.6%）为紧张性精神分裂症。与其他精神分裂症相比，两性患紧张性精神分裂症的风险相同，男性患紧张性精神分裂症的风险更高（1.70,1.42-2.03,P < 0.0001）。与其他精神分裂症相比，父亲年龄的增加对紧张性精神分裂症的风险没有影响，其中35岁以上父亲对后代的风险为1.27 （1.03-1.57,P = 0.03）。紧张性精神分裂症患者更可能有年龄较大的母亲（35岁以上）（相对风险= 2.14,0.85-5.54），而母亲年龄与其他精神分裂症无关。父母有精神分裂症史对两者的影响相同。紧张症患者企图自杀的可能性显著增加（P = 0.006）。在这个队列中，紧张性精神分裂症患者的危险因素与其他类型的精神分裂症患者有所不同，他们更有可能尝试自杀。这在一定程度上支持了紧张性精神分裂症可能有独特病因的假设。
In the 20th century, catatonia was usually deemed a subtype of schizophrenia. Recently, the nature and classification of catatonia are being reconsidered. This study is the first to describe catatonia using prospectively collected data and to examine how catatonic schizophrenia differs from, or resembles, other types of schizophrenia.Data were analyzed in a cohort of 90 079 offspring followed from birth till ages 29-41 years. Proportional hazards models were used, calculating time to first psychiatric hospital admission, to compare risk factors for catatonic schizophrenia vs "other schizophrenia."Of 568 cases of schizophrenia, 43 (7.6%) had catatonic schizophrenia. The sexes were equally at risk for catatonic schizophrenia in contrast to other schizophrenia, for which the incidence was higher in males (1.70, 1.42-2.03, P < .0001). Advancing paternal age had no influence on the risk of catatonic schizophrenia in contrast to other schizophrenia, in which the risk to offspring of fathers age 35+ was 1.27 (1.03-1.57, P = .03) compared with those of younger fathers. Those with catatonic schizophrenia were somewhat more likely to have older mothers (aged 35+) (relative risk = 2.14, 0.85-5.54) while maternal age was not related to other schizophrenia. Both were equally affected by parental history of schizophrenia. Patients with catatonia were significantly more likely to attempt suicide (P = .006).Patients with catatonic schizophrenia show a somewhat different profile of risk factors from those with other types of schizophrenia in this cohort and are more likely to attempt suicide. This lends some support to the hypothesis that catatonic schizophrenia may have a distinct etiology.