Association of reduced sclerostin expression with collapse process in patients with osteonecrosis of the femoral head
Association of reduced sclerostin expression with collapse process in patients with osteonecrosis of the femoral head
复制标题
股骨头坏死患者硬化蛋白表达减少与塌陷过程的关系
DOI：
10.1007/s00264-018-3979-7
复制
发表时间：
2018-07-01
影响因子：
2.7
通讯作者：
He, Wei
中科院分区：
文献类型：
--
作者：
Chen, Xiao-Jun;Yang, Fan;He, Wei
目的硬化蛋白是一种骨细胞衍生的蛋白质，对成骨细胞活性具有有效的抑制作用。各种原因引起的股骨头坏死(ONFH)引起的骨细胞凋亡在促进股骨头塌陷中起关键作用。但改变硬化素水平对 ONFH 崩溃的影响尚未研究。我们的目的是评估硬化蛋白水平在 ONFH 崩溃中的作用。方法 2016 年 5 月至 2016 年 11 月期间，236 名受试者参加了本研究。根据骨循环研究协会（ARCO）分类对患者进行分类。评估临床骨组织形态、硬化蛋白表达位置和水平以及血浆硬化蛋白水平。结果非创伤性ONFH组硬化蛋白水平显着低于健康对照组（P= 0.002）。硬化蛋白水平与ARCO分期呈负相关（r= − 0.239，P= 0.009），并且在塌陷后组中显着降低（P= 0.025）。结论 硬化蛋白表达的减少可能在ONFH塌陷过程中起关键作用，并可预测ONFH的疾病进展。
PurposeSclerostin is an osteocyte-derived protein that has a potent inhibitory effect on osteoblast activity. The osteocyte apoptosis induced by various causes of osteonecrosis of the femoral head (ONFH) plays a key role in the promotion of femoral head collapse. But the effect of altering sclerostin level on the collapse of ONFH has not been studied. Our aim was to assess the role of sclerostin level in the collapse of ONFH.MethodsBetween May 2016 and November 2016, 236 subjects were enrolled in the present study. The patients were classified according to the Association Research Circulation Osseous (ARCO) classification. The clinical bone histomorphology, the expression position, and level of sclerostin as well as the plasma sclerostin level were evaluated.ResultsThe sclerostin level was significantly lower in the non-traumatic ONFH group than those in the healthy control group (P= 0.002). The sclerostin level was negatively associated with ARCO stages (r= − 0.239,P= 0.009) and significantly lower in the postcollapse group (P= 0.025).ConclusionsThe reduced expression of sclerostin may play a key role in the collapse process of ONFH and be predictive of the disease progression of ONFH.