Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma:: three meta-analyses of updated individual data
Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma:: three meta-analyses of updated individual data
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DOI：
10.1016/s0140-6736(00)90011-4
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发表时间：
2000-03-18
期刊：
影响因子：
168.9
通讯作者：
Designé, L
中科院分区：
文献类型：
--
作者：
Pignon, JP;Bourhis, J;Designé, L
背景：尽管有70多项随机试验，化疗对非转移性头颈部鳞状细胞癌的疗效仍不确定。方法我们更新了1965至1993年间所有随机试验中所有患者的数据，包括口咽癌、口腔癌、喉癌或下咽癌。在63项局部区域治疗试验(10741例患者)的主要荟萃分析中发现，合并死亡风险比为0.90(95%可信区间0.85-0.94，P
Background Despite more than 70 randomised trials, the effect of chemotherapy on non-metastatic head and neck squamous-cell carcinoma remains uncertain. We did three meta-analyses of the impact of survival on chemotherapy added to locoregional treatment.Methods We updated data on all patients in randomised trials between 1965 and 1993, We included patients with carcinoma of the oropharynx, oral cavity, larynx, or hypopharynx.Findings The main meta-analysis of 63 trials (10 741 patients) of locoregional treatment with or without chemotherapy yielded a pooled hazard ratio of death of 0.90 (95% CI 0.85-0.94, p