Suppression of food intake by intravenous nutrients and insulin in the baboon.
Suppression of food intake by intravenous nutrients and insulin in the baboon.
复制标题
通过静脉注射营养物质和胰岛素抑制狒狒的食物摄入。
DOI：
10.1152/ajpregu.1984.247.2.r393
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
PorteJr,D
中科院分区：
文献类型：
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作者：
Woods,SC;Stein,LJ;McKay,LD;PorteJr,D
静脉营养物按每日总基线热量摄入的 25% 和 50% 输注，以确定循环因素对年轻成年雄性狒狒 (Papio cynocephalus) 自发食物摄入的作用。当输注总热量的 25%（P 小于 0.05）时，葡萄糖输注抑制食物摄入量（15.1%）；当输注总热量的 50%（P 小于 0.05）时，葡萄糖输注抑制食物摄入量（P 小于 0.05）41.8%，持续 14-21 天。两种输注均产生基础高血糖（25% 葡萄糖期间为 82-172 mg/dl，50% 葡萄糖期间为 120-239 mg/dl）。两种输注还导致循环胰岛素增加（25%葡萄糖期间为48.1-63.1 microU/ml，50%葡萄糖期间为68.5-77.2 microU/ml）。同时输注外源胰岛素（0.33 mU X kg-1 X min-1）可预防高血糖（25%葡萄糖期间为85.8-87.9 mg/dl），但维持基础外周胰岛素水平升高（52.4-84.4 microU/ml）。食物摄入量减少 13%（P 小于 0.05）与单独输注葡萄糖相似。输注每日总热量 25% 和 50% 的英脱利匹特（Intralipid）也可抑制自发食物摄入，但不会产生高血糖或胰岛素水平升高。抑制程度与葡萄糖相似：输注 25% 基础热量时为 16%（P 小于 0.05），输注 50% 基础热量时为 31.3%（P 小于 0.05）。然而，这种模式有所不同，它的作用更快，而且往往会随着时间的推移而减弱，而不是葡萄糖的缓慢作用，这种作用可以维持 14 天。我们得出的结论是，循环营养物质可以独立于灵长类动物的胃肠道吸收来调节食物摄入量。（摘要截断为 250 字）
Intravenous nutrients were infused at 25 and 50% of total base-line daily caloric intake to determine the role of circulating factors on spontaneous food ingestion in young adult male baboons (Papio cynocephalus). Glucose infusion suppressed food intake (15.1%) when 25% of total calories was infused (P less than 0.05) and 41.8% when 50% of total calories was infused (P less than 0.05) for 14-21 days. Both infusions produced basal hyperglycemia (82-172 mg/dl during 25% glucose and 120-239 mg/dl during 50% glucose). Both infusions also caused an increase in circulating insulin (48.1-63.1 microU/ml during 25% glucose and 68.5-77.2 microU/ml during 50% glucose). The simultaneous infusion of exogenous insulin (0.33 mU X kg-1 X min-1) prevented hyperglycemia (85.8-87.9 mg/dl during 25% glucose) but maintained raised basal peripheral insulin levels (52.4-84.4 microU/ml). The 13% suppression of food intake (P less than 0.05) was similar to glucose infusion alone. Comparable infusions of Intralipid as 25 and 50% of total daily calories also suppressed spontaneous food intake but did not produce hyperglycemia or elevated insulin levels. The magnitude of suppression was similar to that of glucose: 16% when 25% of basal calories was infused (P less than 0.05) and 31.3% when 50% of basal calories was infused (P less than 0.05). However, the pattern was different with a more rapid effect, which tended to diminish in time, rather than the slow effect found with glucose, which was maintained for 14 days. We conclude that circulating nutrients can regulate food intake independent of gastrointestinal absorption in primates.(ABSTRACT TRUNCATED AT 250 WORDS)