Nano hydroxyapatite induces glioma cell apoptosis by suppressing NF-B signaling pathway
Nano hydroxyapatite induces glioma cell apoptosis by suppressing NF-B signaling pathway
复制标题
纳米羟基磷灰石通过抑制 NF-κB 信号通路诱导胶质瘤细胞凋亡。
DOI：
10.3892/etm.2019.7418
复制
发表时间：
2019-05-01
影响因子：
2.7
通讯作者：
Wang, Chao
中科院分区：
文献类型：
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作者：
Guo, Guocai;Tian, Ang;Wang, Chao
纳米羟基磷灰石（nHA）颗粒已被证明对多种癌细胞系和癌症生物学动物模型发挥抗癌作用。然而，nHA颗粒对胶质瘤细胞的作用的分子机制仍不清楚。本研究旨在观察nHA对胶质瘤细胞行为的影响，并探讨其分子机制。将大鼠神经胶质瘤C6细胞和人神经胶质瘤U87 MG ATCC细胞暴露于nHA（20-100 μ g/ml），并分析其对细胞形态、活力、凋亡、细胞周期、侵袭和核因子（NF）-B信号传导的影响。将C6和U87 MG ATCC细胞暴露于20 μ g/ml nHA 24小时引起细胞脱离。nHA以剂量依赖性方式显著降低C6和U87 MG ATCC细胞的活力（P
Nano-sized hydroxyapatite (nHA) particles have been demonstrated to exert anti-cancer effects on multiple cancer cell lines and animal models of cancer biology. However, the molecular mechanism underlying the effects of nHA particles on glioma cells remains unclear. The present study aimed to examine the effects of nHA on the behavior of glioma cells and investigate its underlying molecular mechanism. Rat glioma C6 cells and human glioma U87MG ATCC cells were exposed to nHA (20-100 mu g/ml), and its effects on cell morphology, viability, apoptosis, cell cycle, invasion and nuclear factor (NF)-B signaling were analyzed. Exposure of C6 and U87MG ATCC cells to 20 mu g/ml nHA for 24 h caused cell detachment. Viability of C6 and U87MG ATCC cells were significantly reduced by nHA in a dose-dependent manner (P