Low Heart Rate Variability in a 2-Minute Electrocardiogram Recording Is Associated with an Increased Risk of Sudden Cardiac Death in the General Population: The Atherosclerosis Risk in Communities Study
Low Heart Rate Variability in a 2-Minute Electrocardiogram Recording Is Associated with an Increased Risk of Sudden Cardiac Death in the General Population: The Atherosclerosis Risk in Communities Study
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DOI：
10.1371/journal.pone.0161648
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发表时间：
2016-08-23
期刊：
影响因子：
3.7
通讯作者：
Chen, Lin Y.
中科院分区：
文献类型：
--
作者：
Maheshwari, Ankit;Norby, Faye L.;Chen, Lin Y.
在一般人群中，低心率变异性（HRV）与总死亡率增加有关;然而，低HRV与心源性猝死（SCD）之间的关系尚不清楚。本研究的目的是评估低心率变异性和SCD之间的关系，在以社区为基础的队列。我们的队列由来自社区动脉粥样硬化风险（ARIC）研究的12，543名参与者组成。心率变异性指标来自基线检查（1987-89）期间获得的2分钟心电图记录。时域测量包括所有正常RR间期的标准差（SDNN）和均方根连续差（r-MSSD）。频域测量包括低频功率（LF）和高频功率（HF）。在13年的中位随访期间，从2001年所有冠心病死亡的医生裁定中确定了215例SCD。在多变量校正的考克斯比例风险模型中，SDNN、LF和HF的每个标准差降低分别与SCD风险增加24%、27%和16%相关。在一般人群中，低HRV与SCD风险增加独立相关。
Low heart rate variability (HRV) has been linked to increased total mortality in the general population; however, the relationship between low HRV and sudden cardiac death (SCD) is less well-characterized. The goal of this study was to evaluate the relationship between low HRV and SCD in a community-based cohort. Our cohort consisted of 12,543 participants from the Atherosclerosis Risk in Communities (ARIC) study. HRV measures were derived from 2-minute electrocardiogram recordings obtained during the baseline exam (1987-89). Time domain measurements included the standard deviation of all normal RR intervals (SDNN) and the root mean squared successive difference (r-MSSD). Frequency domain measurements included low frequency power (LF) and high frequency (HF) power. During a median follow-up of 13 years, 215 SCDs were identified from physician adjudication of all coronary heart disease deaths through 2001. In multivariable adjusted Cox proportional hazards models, each standard deviation decrement in SDNN, LF, and HF were associated with 24%, 27% and 16% increase in SCD risk, respectively. Low HRV is independently associated with increased risk of SCD in the general population.