Liver function, plasma dexamethasone, and DST results in detoxified alcoholics.
Liver function, plasma dexamethasone, and DST results in detoxified alcoholics.
复制标题
肝功能、血浆地塞米松和药敏试验可导致酗酒者解毒。
DOI：
10.1016/0165-1781(89)90163-7
复制
发表时间：
1989
影响因子：
11.3
通讯作者：
Galanter,M
中科院分区：
文献类型：
--
作者：
Carson,SW;Halbreich,U;Yeh,CM;Galanter,M
Alcohol abuse, alcohol withdrawal, and deterioration of hepatic function have been associated with abnormal dexamethasone suppression test (DST) results. Chronic alcohol abuse may also directly alter the pharmacokinetic disposition of dexamethasone. Plasma dexamethasone concentrations following a DST were determined in 53 detoxified alcoholics. Those with abnormal liver function had higher 4 p.m. plasma dexamethasone concentrations and lower DST cortisol concentrations. Those with normal liver function had lower plasma dexamethasone and higher DST cortisol concentrations consistent with induction of hepatic metabolic enzymes from chronic use of alcohol. The data indicate that liver function is one of the variables influencing dexamethasone disposition and DST cortisol suppression.
